Article

New pentahydroxylated steroids from the South China Sea gorgonian Subergorgia suberosa.

Department of Chemistry, Jinan University, Guangzhou 510632, PR China.
Chemistry & Biodiversity (Impact Factor: 1.81). 02/2012; 9(2):370-5. DOI:10.1002/cbdv.201100031
Source: PubMed

ABSTRACT Two new pentahydroxylated steroids, (3β,12β,16β,23E)-cholesta-5,23-diene-3,12,16,20,25-pentaol (1) and (3β,12β,16β)-cholesta-5,25(26)-diene-3,12,16,20,24-pentaol (2), were isolated from the EtOH extract of the South China Sea gorgonian Subergorgia suberosa. In addition, four known steroids were detected. The structures of these compounds were established by spectroscopic methods and comparison of their data with those of the related known compounds. In addition, the cyctotoxicities of the compounds were evaluated against selected cancer cell lines.

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