Article

GSTO and AS3MT genetic polymorphisms and differences in urinary arsenic concentrations among residents in Bangladesh.

Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA.
Biomarkers (impact factor: 2.21). 02/2012; 17(3):240-7. DOI:10.3109/1354750X.2012.658863 pp.240-7
Source: PubMed

ABSTRACT We determined whether single nucleotide polymorphisms (SNPs) in the glutathione S-transferase omega (GSTO) and arsenic(III)methyltransferase (AS3MT) genes were associated with concentrations of urinary arsenic metabolites among 900 individuals without skin lesions in Bangladesh. Four SNPs were assessed in these genes. A pathway analysis evaluated the association between urinary arsenic metabolites and SNPs. GSTO1 rs4925 homozygous wild type was significantly associated with higher monomethylarsonic acid (MMA) and dimethylarsinic acid urinary concentrations, whereas wild-type AS3MT rs11191439 had significantly lower levels of As(III) and MMA. Genetic polymorphisms GSTO and As3MT modify arsenic metabolism as evidenced by altered urinary arsenic excretion.

0 0
 · 
0 Bookmarks
 · 
54 Views
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

900 individuals
 
arsenic metabolism
 
As3MT
 
dimethylarsinic acid urinary concentrations
 
Genetic polymorphisms GSTO
 
glutathione S-transferase omega
 
GSTO
 
GSTO1 rs4925 homozygous wild type
 
higher monomethylarsonic acid
 
MMA
 
pathway analysis
 
single nucleotide polymorphisms
 
SNPs
 
urinary arsenic excretion
 
urinary arsenic metabolites