Oxidases and reactive oxygen species during hematopoiesis: A focus on megakaryocytes

Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA.
Journal of Cellular Physiology (Impact Factor: 3.84). 10/2012; 227(10):3355-62. DOI: 10.1002/jcp.24071
Source: PubMed


Reactive oxygen species (ROS), generated as a result of various reactions, control an array of cellular processes. The role of ROS during megakaryocyte (MK) development has been a subject of interest and research. The bone marrow niche is a site of MK differentiation and maturation. In this environment, a gradient of oxygen tension, from normoxia to hypoxia results in different levels of ROS, impacting cellular physiology. This article provides an overview of major sources of ROS, their implication in different signaling pathways, and their effect on cellular physiology, with a focus on megakaryopoiesis. The importance of ROS-generating oxidases in MK biology and pathology, including myelofibrosis, is also described.

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Available from: Shinobu Matsuura, May 22, 2014
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    • "ROS generation is involved in LPA 3 -mediated MK differentiation Since β-catenin was identified as a mediator of LPA 2 signaling, we further explored the possible downstream of LPA 3 that may involve in megakaryopoiesis. It has been reported that ROS play essential roles in MK maturation [44]. Our previous study on LPA established a model that LPA 3 activates phospholipase-C (PLC), PKC-δ and the ROS signaling cascades, to enhance vascular endothelial growth factor C (VEGF-C) expression in prostate cancer cells [45] [46]. "

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