Article

Oxidases and reactive oxygen species during hematopoiesis: a focus on megakaryocytes.

Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA.
Journal of Cellular Physiology (impact factor: 3.87). 02/2012; 227(10):3355-62. DOI:10.1002/jcp.24071
Source: PubMed

ABSTRACT Reactive oxygen species (ROS), generated as a result of various reactions, control an array of cellular processes. The role of ROS during megakaryocyte (MK) development has been a subject of interest and research. The bone marrow niche is a site of MK differentiation and maturation. In this environment, a gradient of oxygen tension, from normoxia to hypoxia results in different levels of ROS, impacting cellular physiology. This article provides an overview of major sources of ROS, their implication in different signaling pathways, and their effect on cellular physiology, with a focus on megakaryopoiesis. The importance of ROS-generating oxidases in MK biology and pathology, including myelofibrosis, is also described.

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Keywords

bone marrow niche
 
cellular physiology
 
cellular processes
 
different levels
 
different signaling pathways
 
impacting cellular physiology
 
major sources
 
megakaryopoiesis
 
MK biology
 
MK differentiation
 
myelofibrosis
 
normoxia
 
Reactive oxygen species
 
ROS
 
ROS-generating oxidases