Temporal Order Memory Assessed during Spatiotemporal Navigation As a Behavioral Cognitive Marker for Differential Alzheimer's Disease Diagnosis

Pierre et Marie Curie Paris 6 University, Navigation, Memory and Aging Team, Equipe Navigation Memoire et Vieillissement team, UMR7102, CNRS, F75005 Paris, France.
The Journal of Neuroscience : The Official Journal of the Society for Neuroscience (Impact Factor: 6.75). 02/2012; 32(6):1942-52. DOI: 10.1523/JNEUROSCI.4556-11.2012
Source: PubMed

ABSTRACT Episodic memory impairment is a hallmark for early diagnosis of Alzheimer's disease. Most actual tests used to diagnose Alzheimer's disease do not assess the spatiotemporal properties of episodic memory and lead to false-positive or -negative diagnosis. We used a newly developed, nonverbal navigation test for Human, based on the objective experimental testing of a spatiotemporal experience, to differentially Alzheimer's disease at the mild stage (N = 16 patients) from frontotemporal lobar degeneration (N = 11 patients) and normal aging (N = 24 subjects). Comparing navigation parameters and standard neuropsychological tests, temporal order memory appeared to have the highest predictive power for mild Alzheimer's disease diagnosis versus frontotemporal lobar degeneration and normal aging. This test was also nonredundant with classical neuropsychological tests. As a conclusion, our results suggest that temporal order memory tested in a spatial navigation task may provide a selective behavioral marker of Alzheimer's disease.

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Available from: Laure Rondi-Reig, Jul 12, 2015
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    • "Our results may have further clinical implications in light of a 2012 report that impaired temporal order memory may be a selective behavioral marker of Alzheimer disease (Bellassen et al, 2012). In coming years, these combined findings could have particular meaning for the growing number of people with HIV infection who are living into their 60s and beyond (High et al, 2012). "
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    ABSTRACT: To compare temporal order memory in older adults with and without human immunodeficiency virus (HIV) infection. The frontal and temporal lobes play a key role in temporal order memory for items in a sequence. HIV-associated episodic memory deficits correlate with damage to neocortical interneurons in the fronto-striato-thalamo-cortical pathway and with atypical activation of the medial temporal lobes. Therefore, temporal order memory may be sensitive to neuropathological changes in individuals with HIV. In this study, 50 HIV-seropositive individuals aged ≥ 50 years and 50 seronegative controls performed a computerized visuospatial temporal order memory task. During the sample phase of each trial, participants were shown circles presented 1 at a time in a random sequence at the end of each of the 8 arms of a radial maze. During the choice phase, they were shown the maze with a circle at the ends of 2 of the arms and asked which circle had appeared earlier than the other in the original sequence. Performance in both groups improved as a function of greater temporal separation between circle presentations. However, the HIV group had significantly worse memory impairment across all temporal separations, and the impairment was independently associated with clinical deficits in executive function and delayed retrospective memory. Our results extend prior findings that HIV is associated with deficits in strategic aspects of memory encoding and retrieval. The neural mechanisms warrant further research, as do potential impacts on everyday function, eg, adherence to antiretroviral drug regimens.
    Cognitive and behavioral neurology: official journal of the Society for Behavioral and Cognitive Neurology 12/2013; 26(4):171-80. DOI:10.1097/WNN.0000000000000013 · 1.14 Impact Factor
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    • "More importantly with the Pirogovsky et al. (2009) report, impaired performance for temporal ordering was correlated with time to symptom onset in individuals with the mutation underlying Huntington's Disease--suggesting temporal ordering may be an endophenotype or prodromal feature that can be used to characterize the disease. In fact, temporal processing deficits have been reported in Alzheimer's Disease (Bellassen, et al., 2012), Parkinson's Disease (Sagar, et al., 1988), Huntington's Disease (Pirogovsky, et al., 2009), fragile X-associated disorders (Hunsaker, 2012; Johnson-Glenberg, 2008; Simon, 2011), schizophrenia (Davalos, et al., 2003a,b), and autism spectrum disorders (Allman, et al., 2011). "
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    ABSTRACT: In order to overcome difficulties in evaluating cognitive function in mouse models of genetic disorders, it is critical to take into account the background strain of the mouse and reported phenotypes in the clinical population being studied. Recent studies have evaluated cognitive function across a number of background strains and found that spatial memory assayed by the water maze and contextual fear conditioning often does not provide optimal results. The logical extension to these results is to emphasize not only spatial, but all attributes or domains of memory function in behavioral phenotyping experiments. A careful evaluation of spatial, temporal, sensory/perceptual, affective, response, executive, proto-linguistic, and social behaviors designed to specifically evaluate the cognitive function each mouse model can be performed in a rapid, relatively high throughput manner. Such results would not only provide a more comprehensive snapshot of brain function in mouse disease models than the more common approach that approaches nonspecific spatial memory tasks to evaluate cognition, but also would better model the disorders being studied.
    Behavioral Neuroscience 06/2012; 126(3):371-80. DOI:10.1037/a0028453 · 3.25 Impact Factor
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    • "Behavioral interventions that minimize temporal interference and structure daily living tasks into repetitive, fixed sequences may improve memory and perhaps could increase functional independence in older adults. In addition, a recent study reports that impaired temporal order memory may be a selective behavioral marker of Alzheimer's disease (Bellassen et al. 2012). Therefore, "
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    ABSTRACT: Two experiments tested the effect of temporal interference on order memory for fixed and random sequences in young adults and nondemented older adults. The results demonstrate that temporal order memory for fixed and random sequences is impaired in nondemented older adults, particularly when temporal interference is high. However, temporal order memory for fixed sequences is comparable between older adults and young adults when temporal interference is minimized. The results suggest that temporal order memory is less efficient and more susceptible to interference in older adults, possibly due to impaired temporal pattern separation.
    Learning & memory (Cold Spring Harbor, N.Y.) 05/2012; 19(6):251-5. DOI:10.1101/lm.026062.112 · 4.38 Impact Factor
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