Article

Isolation, structural elucidation, and cytotoxicity of three new ent-kaurane diterpenoids from Isodon japonica var. glaucocalyx.

School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, P. R. China.
Planta Medica (impact factor: 2.15). 02/2012; 78(6):589-96. DOI:10.1055/s-0031-1298265 pp.589-96
Source: PubMed

ABSTRACT Three new ENT-kaurane diterpenoids, glaucocalyxin H ( 1), glaucocalyxin I ( 2), and glaucocalyxin J ( 3), together with four known diterpenoids ( 4- 7), were isolated from the leaves of Isodon japonica Hara var. glaucocalyx. Their structures were elucidated by spectroscopic analysis, and the structures of compounds 2 and 3 were further confirmed by X-ray crystallographic analysis. Compounds 1, 4, and 5 were evaluated for their cytotoxicity IN VITRO against CE-1, U87, A-549, MCF-7, Hela, K-562, and HepG-2 human tumor cell lines. Compound 1 showed potent inhibitory activities against six tumor cell lines with IC (50) values ranging from 1.86-10.95 µM, and compounds 4 and 5 exhibited significant selective cytotoxicity on seven tumor cell lines.

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Keywords

5 exhibited significant selective cytotoxicity
 
CE-1
 
compounds 2
 
compounds 4
 
glaucocalyx
 
glaucocalyxin
 
glaucocalyxin H
 
glaucocalyxin J
 
HepG-2 human tumor cell lines
 
Isodon japonica Hara var
 
MCF-7
 
new ENT-kaurane diterpenoids
 
potent inhibitory activities
 
spectroscopic analysis
 
structures
 
X-ray crystallographic analysis
 

Hui-Juan Liang