Article

The expression of HSPs, anti-oxidants, and cytokines in plasma and bronchoalveolar lavage fluid of patients with acute respiratory distress syndrome.

Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Korea University College of Medicine, Republic of Korea.
Clinical biochemistry (impact factor: 2.02). 01/2012; 45(6):493-8. DOI:10.1016/j.clinbiochem.2012.01.020 pp.493-8
Source: PubMed

ABSTRACT We studied several acute inflammatory materials (AIM) such as various inflammatory cytokines, oxidative stress, and heat shock proteins in ARDS patients by simultaneously measuring from bronchoalveolar lavage fluid (BALF) and plasma.
AIM were measured by using plasma and BALF sampling obtained from ARDS group (n=12) and non-ARDS group (n=12).
In the BALF, only HSP 47 was significantly increased in ARDS group than non-ARDS group. In plasma, GRP 94, HSP 90, HSP 60, HSP 47, GPx-3, and IL-8 were increased significantly in ARDS group. In short, most of the AIM in BALF or plasma were not significantly different in ARDS group as compared with non-ARDS group. Ninety-day mortality was significantly related to HSP90, HSP 60 and GPx-3 in plasma but not in BALF.
Alteration of AIM levels in both BALF or plasma of ARDS group was not remarkable compared with the non-ARDS group. Our result suggests the need to reconsider ARDS pathophysiology and therapeutic strategy.

0 0
 · 
0 Bookmarks
 · 
29 Views
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

acute inflammatory materials
 
ARDS group
 
BALF
 
BALF sampling
 
bronchoalveolar lavage fluid
 
heat shock proteins
 
IL-8
 
Ninety-day mortality
 
non-ARDS group
 
oxidative stress
 
plasma
 
therapeutic strategy
 
various inflammatory cytokines
 

Eun Joo Lee