Article

[Gender- and age-related differences in dosage and serum concentration of psychotropic drugs].

Seksjon for psykiatrisk forskning og undervisning, Diakonhjemmet Sykehus, Norway.
Tidsskrift for den Norske laegeforening 02/2012; 132(3):288-91. DOI: 10.4045/tidsskr.10.1317
Source: PubMed

ABSTRACT The dose recommendations in the Norwegian Pharmaceutical Product Compendium (Felleskatalogen) are not gender-specific, despite evidence of gender-dependent differences in the metabolism of a number of drugs. The purpose of this study was to investigate the extent to which age and gender influence the prescription and serum concentration of psychotropic drugs.
The prescribed doses and serum concentrations of antidepressant, antipsychotic and antiepileptic drugs were studied in relation to age and gender in 1533 patients.
Elderly women (≥ 65 years) were given somewhat lower doses of antidepressant drugs, but they had significantly higher serum concentrations than younger patients of either gender. Antidepressant drugs were prescribed in fairly high doses in the study population; the median number of defined daily doses was 1.5.
The study suggests that when prescribing drugs, Norwegian physicians do not take sufficient account of the effect of age and gender on the pharmacokinetics of antidepressant drugs.

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