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Comparative efficacy of rHaa86 and rBm86 against Hyalomma anatolicum anatolicum and Rhipicephalus (Boophilus) microplus

Entomology Laboratory, Parasitology Division, Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh, India.
Parasite Immunology (Impact Factor: 1.85). 02/2012; 34(6):297-301. DOI: 10.1111/j.1365-3024.2012.01356.x
Source: PubMed

ABSTRACT Hyalomma anatolicum anatolicum and Rhipicephalus (Boophilus) microplus are the most economically important tick species in India and other tropical and subtropical regions of the world and transmit pathogens causing animal and human diseases. We demonstrated that vaccination of animal by rHaa86 could be used for the control of both H. a. anatolicum and R. (B.) microplus infestations. By comparing the efficacy of rHaa86 and rBm86, it was observed that vaccine based on rHaa86 will be more effective in controlling homologous challenge infestations (68·7% against larvae and 45·8% against adults). The results of this trial demonstrated that species-specific antigens are the better choice for vaccine development and could serve as an effective tool for the integrated control of H. a. anatolicum.

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    • "In Hyalomma genus, only the Bm86 ortholog in H. anatolicum (Haa86) was produced [40] [41] [51]. This resulted in the increase of the vaccine efficacy against both adult and immature ticks challenges [40] [41] [51]. Recently, cattle immunization with the Bm86 ortholog in R. appendiculatus (Ra86) was ineffective against R. appendiculatus adult tick. "
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