Strong antiseptic activity of essential oils has been known for a long time. The antibacterial activity of oils was tested against clinical bacterial strains of Staphylococcus, Enterococcus, Escherichia and Pseudomonas genera. The agar diffusion method was used for microbial growth inhibition at various concentrations of the oils from T. vulgaris and L. angustifolia. Susceptibility testing to antibiotics and chemotherapeutics was carried out using disc-diffusion method. 120 strains of bacteria isolated from patients with infections of oral cavity, respiratory, genitourinary tracts and from hospital environment were investigated. The results of experiments showed that the oil from T. vulgaris exhibited extremely strong activity against all of the clinical strains. Thyme oil demonstrated a good efficacy against antibiotics resistant strains of the tested bacteria. Lavender oil has been less activity against clinical strains of Staphylococcus, Enterococcus and Escherichia genus. The worst results have been observed against all strains of Pseudomonas aeruginosa.
"glycosides, phenolic acids, saponins, and also essential oils. Many have strong antibacterial, antifungal, antiviral, antiinflammatory , antioxidant, and also anticancerogenic properties (Sparg et al. 2004; Chanwitheesuk et al. 2005; Ahn et al. 2006; Sienkiewicz et al. 2011). Opportunistic infections caused by Gram-positive cocci belonging to Staphylococcus spp., Enterococcus spp., and Gram-negative bacteria, mainly of the Klebsiella spp., Escherichia spp., Pseudomonas spp., Proteus spp., Enterobacter spp., and Serratia spp. "
[Show abstract][Hide abstract] ABSTRACT: Panax quinquefolium, American ginseng, is valued for its triterpene saponins, known as ginsenosides. These constituents possess a number of pharmacological properties and hairy root cultures can synthesize similar saponins to those of field-cultivated roots. The antibacterial activity of extracts from three hairy root clones of P. quinquefolium L. was tested against a range of standard bacterial and yeast strains. The agar diffusion method was used to evaluate inhibition of microbial growth at various extract concentrations. Commercial antibiotics were used as positive reference standards to determine the sensitivity of the strains. Susceptibility testing to antibiotics was also tested using the disk diffusion method. The minimal inhibitory concentration values of the extracts, obtained by agar diffusion, ranged from 0.8 to 1.4 mg/ml. The results showed that extracts from hairy root cultures inhibited the growth of bacteria and yeast strains and suggest that they may be useful in the treatment of infections caused by pathogenic microorganisms.
[Show abstract][Hide abstract] ABSTRACT: The increasing incidence of drug-resistant pathogens has drawn the attention of the pharmaceutical and scientific communities towards studies on the potential antimicrobial activity of plant-derived substances, an untapped source of antimicrobial chemotypes, which are used in traditional medicine in different countries. The aim of this review is to provide recent insights regarding the possibilities of the most important natural antimicrobial compounds derived from plant sources containing a wide variety of secondary metabolites, which are useful as alternative strategies to control infectious diseases. This review will focus on natural plant products as a useful source of antimicrobial molecules, active in particular, on bacteria and fungi. When considering that many of these compounds, which have been used for centuries, are a source of new drugs and that there are ever-increasing technical breakthroughs, it can be envisaged that in the next years some different molecules discovered by ingenious screening programs and obtained from different plant oils and extracts will become useful therapeutic tools.
[Show abstract][Hide abstract] ABSTRACT: The spreading of bacterial antibiotic resistance among clinical strains of pathogenic bacteria has made investigators to search for other active antibacterial agents which could provide a valuable complement to the existing therapies.
To determine the antibacterial activity of clary sage oil (Salvia sclarea L.) against Staphylococcus clinical strains which were isolated from patients with wound infections.
A comprehensive evaluation of Staphylococcus clinical strain resistance to antibiotics was performed. The constituents of clary sage oil were assayed by GC-FID-MS analysis. The minimal inhibitory concentration (MIC) of the tested essential oil against staphylococci by the micro-dilution broth method was determined.
The clary sage oil was active against Staphylococcus aureus, S. epidermidis and S. xylosus with MIC values ranging from 3.75 to 7.00 µl/ml.
The results of the in vitro tests encourage to use formulations containing sage oil as the active natural antimicrobial agent. Because of its antimicrobial properties clary sage oil may be applied to treat wounds and skin infections.
Brock A Arivett, Steven E Fiester, Emily J Ohneck, William F Penwell, Cynthia M Kaufman, Ryan F Relich, Luis A Actis
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