Article

Synthesis and antitubercular activity of new L-serinyl hydrazone derivatives.

Fundação Oswaldo Cruz, Instituto de Tecnologia em Fármacos-Far Manguinhos, Fundação Oswaldo Cruz, 21041-250, Rio de Janeiro, RJ, Brazil.
Medicinal chemistry (Shāriqah (United Arab Emirates)) (impact factor: 1.64). 11/2011; 7(6):611-23. pp.611-23
Source: PubMed

ABSTRACT A series of 32 L-serinyl hydrazone derivatives have been synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv, being also evaluated their cell viabilities in non infected and infected macrophages with Mycobacterium bovis Bacillus Calmette-Guerin (BCG). The compounds 8c, 8e, 8h and 8i, were non-cytotoxic and exhibited an important minimum inhibitory concentration (MIC) activity between 25 and 100 μg/mL, which can be compared with that of the tuberculostatic drug D-cicloserine (5-20 μg/mL).

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Keywords

32 L-serinyl hydrazone derivatives
 
macrophages
 
MIC
 
Mycobacterium tuberculosis H37Rv
 
tuberculostatic drug D-cicloserine
 
vitro antibacterial activity