Article

Persistence of diarrheal pathogens is associated with continued recruitment of plasmablasts in the circulation.

Division of Infectious Diseases, Department of Medicine, Helsinki University Central Hospital, Aurora Hospital, POB 348, 00029 Helsinki, Finland.
Clinical and Developmental Immunology (impact factor: 1.84). 01/2012; 2012:279206. DOI:10.1155/2012/279206 pp.279206
Source: PubMed

ABSTRACT Intestinal antigen encounter leads to recirculation of antigen-specific plasmablasts via lymphatics and blood back to the intestine. Investigating these gut-originating cells in blood provides a less invasive tool for studying intestinal immune responses, with the limitation that the cells disappear from the circulation in two weeks. No data exist on situations where pathogens persist in the intestine. Patients with Salmonella, Yersinia, or Campylobacter gastroenteritis and volunteers receiving an oral typhoid vaccine were assayed for plasmablasts specific to each subject's own pathogen/antigen weekly until the response faded. In vaccinees, plasmablasts disappeared in two weeks. In gastroenteritis, the response faded 2-3 and 3-7 weeks after the last positive Salmonella or Yersinia stool culture. Even in symptomless patients, pathogens persisting in the intestine keep seeding plasmablasts into the circulation. Assaying these cells might offer a powerful tool for research into diseases in which persisting microbes have a potential pathogenetic significance.

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    Oncogene 01/2009; 28(8):1099-109. · 6.37 Impact Factor
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

3-7 weeks
 
antigen-specific plasmablasts
 
Campylobacter gastroenteritis
 
diseases
 
gut-originating cells
 
Intestinal antigen encounter
 
intestinal immune responses
 
intestine
 
invasive tool
 
oral typhoid vaccine
 
pathogens persisting
 
Patients
 
persisting microbes
 
plasmablasts specific
 
potential pathogenetic significance
 
powerful tool
 
seeding plasmablasts
 
subject's own pathogen/antigen weekly
 
symptomless patients
 
Yersinia stool culture