Article

IL-6 and IL-13 in induced sputum of COPD and asthma patients: correlation with respiratory tests.

Department of Internal Medicine, Pneumology and Allergology, Medical University of Warsaw, Warsaw, Poland.
Respiration (impact factor: 2.26). 02/2012; 84(2):101-7. DOI:10.1159/000334900 pp.101-7
Source: PubMed

ABSTRACT IL-6 is strongly implicated in the development of chronic obstructive pulmonary disease (COPD). IL-13 is the well-documented central mediator in allergic asthma. IL-6 is attributed to the proinflammatory activities in COPD as well as asthma. In COPD patients exacerbation is increased by serum IL-6. The association of IL-13 as well as IL-6 with the impaired respiratory function of asthma patients remains controversial.
The aim of this study was to compare the concentration of IL-6 and IL-13 in the induced sputum of asthma and COPD patients, and to assess the possible association of these cytokines with the impairment of lung function.
Twenty-six subjects with COPD and 18 subjects with asthma were enrolled in this study. IL-6 and IL-13 levels were measured in induced sputum by ELISA and correlated with the results of respiratory tests.
The induced sputum of COPD patients had a significantly higher IL-6 level than the sputum of asthma subjects while no significant differences were found in the levels of IL-13. There was a statistically significant negative correlation between IL-6 level and FEV(1) or FEV(1)/FVC in asthma patients (r = -0.59 and -0.54, respectively) and a negative correlation that did not reach statistical significance between IL-6 level and FEV(1), FEV(1)% or FVC in COPD subjects (r = -0.30, -0.30 and -0.38, respectively). There was no relationship between concentrations of IL-13 and impaired respiratory function.
Our results confirmed that IL-6, but not of IL-13, is associated with respiratory disorders in both asthma and COPD patients.

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Keywords

18 subjects
 
allergic asthma
 
asthma patients
 
asthma subjects
 
chronic obstructive pulmonary disease
 
COPD patients
 
COPD patients exacerbation
 
COPD subjects
 
higher IL-6 level
 
IL-13 levels
 
IL-6 level
 
impaired respiratory function
 
induced sputum
 
lung function
 
possible association
 
respiratory disorders
 
respiratory function
 
respiratory tests
 
serum IL-6
 
well-documented central mediator