Psychological comorbidities in Chinese patients with acute-on-chronic liver failure

Beijing YouAn Hospital, Capital Medical University, Beijing 100069, China.
General hospital psychiatry (Impact Factor: 2.61). 02/2012; 34(3):276-81. DOI: 10.1016/j.genhosppsych.2011.11.012
Source: PubMed


Patients with acute-on-chronic liver failure (ACLF) experience long-term chronic liver diseases plus an acute liver function decompensation. This study aimed to determine whether psychological symptoms in patients with hepatitis B virus (HBV)-related ACLF differ from those with other chronic liver diseases and to identify which factors could predict psychological impairment in liver patients.
This was a paired case-control study. A total of 120 inpatients, including 40 cases for HBV-related ACLF, 40 paired controls for HBV-related cirrhosis and 40 paired controls for chronic hepatitis B (CHB), as well as 40 paired healthy controls were studied.
A high proportion of patients with HBV-related ACLF were classified as Child's stage C. The prevalence of depression in patients with HBV-related ACLF was significantly higher than in CHB patients and healthy controls, but was equivalent to patients with HBV-related cirrhosis. Patients with HBV-related ACLF had significantly higher level of self-esteem than those with HBV-related cirrhosis. However, there was no significant difference among the three liver patient groups and healthy controls in anxiety and suicide intent. Lower education level, anxiety, poor sleep quality and greater severity of disease were associated with elevated depression.
Patients with HBV-related ACLF and cirrhosis are at higher risk of depression. It appears that severity of liver disease measured by Child-Pugh class, rather than additional acute liver function decompensation, significantly predicted depression among liver patients.

9 Reads
  • [Show abstract] [Hide abstract]
    ABSTRACT: Aim: To investigate incidence of depression and its risk factors in inpatients with gastrointestinal diseases in department of gastroenterology of general hospital. Methods: A hospital cross-sectional study was performed. HAMD and SDS were used to assess the depression scores in 338 inpatients with GI diseases in department of gastroenterology of the First Affiliated Hospital of Dalian Medical University. Results: 1. The total incidence of depression was 27.50% in inpatients in gastroenterology department; 2. The incidence of depression in GI disease was 26.60%; 3. The incidence of depression was higher in female (31.9%) than that in male inpatients (22.2%)(P<;0.05); 4. In the three subtypes of GERD, the depression scores in patients with NERD were higher than that in patients with EE and BE (P<;0.05); 5. Female, unhappy marriage, recent negative life events, long course of disease and a family history of severe disease are the possible depression risk factors. Conclusion: The incidence of depression in inpatients with GI diseases in department of gastroenterology of general hospital is high, and is related with the severity of diseases. Antidepressant treatment should be given to the GI inpatients with depression, especially to those with depression risk factors.
    2014 11th IEEE International Conference on Control & Automation (ICCA); 06/2014
  • [Show abstract] [Hide abstract]
    ABSTRACT: Compared to data on adolescents and adults, limited research has been conducted on biological correlates among young children with possible psychological difficulties, especially in Asian countries. By focusing on various peripheral biochemical indicators, we investigated potential biological correlates of psychological states in a community sample of Taiwanese school children aged 6–10 years. In total, 307 students (159 obese children and 148 normal-weight children) were selected from first- and fourth-grade school children in eight elementary schools in the Taipei metropolitan area in 2009. These children underwent a comprehensive health examination, including a physical examination, blood sample analysis, and questionnaire administration in a hospital. Differences in anthropometric and serum biochemical readings were compared between children with average and worse levels on each of the five psychological domains. We found that interleukin (IL)-1β [β = 1.29, 95 % confidence interval (CI) 0.50–2.09], IL-10 (β = 1.61, 95 % CI β = 0.08, 95 % CI 0.01–0.15), homocysteine (β = 0.63, 95 % CI 0.09–1.18), and aspartate transaminase (AST) (β = 0.15, 95 % CI
    Chinese Science Bulletin 12/2014; 59(35). DOI:10.1007/s11434-014-0617-7 · 1.58 Impact Factor

Similar Publications