Article

The influence of cattle breed on susceptibility to bovine tuberculosis in Ethiopia

Animal Health and Veterinary Laboratories Agency, TB Research Group, New Haw, Addlestone, Surrey KT15 3NB, United Kingdom.
Comparative immunology, microbiology and infectious diseases (Impact Factor: 2.11). 02/2012; 35(3):227-32. DOI: 10.1016/j.cimid.2012.01.003
Source: PubMed

ABSTRACT Bovine tuberculosis in domestic livestock such as cattle is an economically important disease with zoonotic potential, particularly in countries with emerging economies. We discuss the findings of recent epidemiological and immunological studies conducted in Ethiopia on host susceptibility differences between native zebu and the exotic Holstein-Friesian cattle that are increasingly part of the Ethiopian National herd, due to the drive to increase milk yields. These findings support the hypothesis that native Zebu cattle are more resistant to bovine tuberculosis. We also summarise the results of experimental infections that support the epidemiological data, and of laboratory experiments that suggest a role for the innate immune response, and in particular interleukin-6, in the outcome of bovine tuberculosis infection.

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    • "The indigenous cattle and the prevailing extensive rural production systems are unlikely to be able to satisfy the rise in this demand for livestock food products. Therefore, intensification of animal husbandry in developing countries has been sought (Vordermeier et al., 2012). Numerous key factors, combining biological, industrial and political aspects, were involved in these trends, having affected the current genetic status of indigenous cattle breeds, imposing risk on its diversity. "
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    • "occurrence of BTB became rare in humans and cattle in industrialized countries (Ayele et al. 2004; Vordermeier et al. 2012). However, it remains an important disease in many countries of the world where BTB is endemic, causing significant economic losses (Zinsstag et al. 2006). "
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