Article

Occupational exposures among nurses and risk of spontaneous abortion.

National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH 45226, USA.
American journal of obstetrics and gynecology (impact factor: 3.28). 12/2011; 206(4):327.e1-8. DOI:10.1016/j.ajog.2011.12.030 pp.327.e1-8
Source: PubMed

ABSTRACT We investigated self-reported occupational exposure to antineoplastic drugs, anesthetic gases, antiviral drugs, sterilizing agents (disinfectants), and X-rays and the risk of spontaneous abortion in US nurses.
Pregnancy outcome and occupational exposures were collected retrospectively from 8461 participants of the Nurses' Health Study II. Of these, 7482 were eligible for analysis using logistic regression.
Participants reported 6707 live births, and 775 (10%) spontaneous abortions (<20 weeks). After adjusting for age, parity, shift work, and hours worked, antineoplastic drug exposure was associated with a 2-fold increased risk of spontaneous abortion, particularly with early spontaneous abortion before the 12th week, and 3.5-fold increased risk among nulliparous women. Exposure to sterilizing agents was associated with a 2-fold increased risk of late spontaneous abortion (12-20 weeks), but not with early spontaneous abortion.
This study suggests that certain occupational exposures common to nurses are related to risks of spontaneous abortion.

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Keywords

12th week
 
8461 participants
 
anesthetic gases
 
antineoplastic drug exposure
 
antineoplastic drugs
 
antiviral drugs
 
certain occupational exposures common
 
logistic regression
 
nulliparous women
 
Nurses' Health Study II
 
Pregnancy outcome
 
risks
 
self-reported occupational exposure
 
shift work
 
spontaneous abortion
 
sterilizing agents