Article

Regulation of DNA glycosylases and their role in limiting disease.

Center for Research on Occupational and Environmental Toxicology, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, Oregon 97239 - 3098, USA.
Free radical research (impact factor: 2.22). 02/2012; 46(4):460-78. DOI:10.3109/10715762.2012.655730 pp.460-78
Source: PubMed

ABSTRACT This review will present a current understanding of mechanisms for the initiation of base excision repair (BER) of oxidatively-induced DNA damage and the biological consequences of deficiencies in these enzymes in mouse model systems and human populations.

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Keywords

BER
 
biological consequences
 
current understanding
 
human populations
 
mouse model systems