Glutamatergic transmission in schizophrenia: From basic research to clinical practice

Schizophrenia Research Institute, Nathan Kline Institute for Psychiatric Research, New York, USA.
Current opinion in psychiatry (Impact Factor: 3.55). 03/2012; 25(2):96-102. DOI: 10.1097/YCO.0b013e32835035b2
Source: PubMed

ABSTRACT Purpose of review: The past 20 years have seen the glutamatergic hypothesis go from theory to phase III trials of novel mechanism antipsychotics. Recent Findings: We review the recent literature on glutamatergic theory, covering assessment and genetic studies, as well as drug development in animals and humans. Summary: Although evidence continues to accumulate in support of glutamate hypotheses, further research continues to be required and interactions with other key systems need to be explored.

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