Article

No association between IRF3 polymorphism and susceptibility to hepatitis B virus infection in Chinese patients.

Department of Infectious Diseases, The First Affiliated Hospital of Anhui Medical University, Hefei 230032, Anhui Province, China.
World Journal of Gastroenterology (impact factor: 2.47). 01/2012; 18(4):388-92. DOI:10.3748/wjg.v18.i4.388 pp.388-92
Source: PubMed

ABSTRACT To investigate the association between three tag single nucleotide polymorphisms (tagSNPs) in interferon regulatory factors (IRF3) and the genetic susceptibility to chronic hepatitis B virus (HBV) infection.
We performed a case-control study of 985 Chinese cases of chronic HBV infection and 294 self-limiting HBV-infected individuals as controls. Three tagSNPs in IRF3 (rs10415576, rs2304204, rs2304206) were genotyped with the Multiplex SNaPshot technique. The genotype and allele frequencies were calculated and analyzed.
The three SNPs showed no significant genotype/allele associations with chronic HBV infection. Overall allele P values were: rs10415576, P = 0.0908, odds ratio (OR) [95% confidence interval (CI)] = 1.1798 (0.9740-1.4291); rs2304204, P = 0.5959, OR (95% CI) = 1.0597 (0.8552-1.3133); rs2304206, P = 0.8372, OR (95% CI) = 1.0250 (0.8097-1.2976). Overall genotype P values were: rs10415576, P = 0.2106; rs2304204, P = 0.8458; rs2304206, P = 0.8315. There were no statistically significant differences between patients with chronic HBV infection and controls. Haplotypes generated by these three SNPs were also not significantly different between the two groups.
The three tagSNPs of IRF3 are not associated with HBV infection in the Han Chinese population.

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Keywords

294 self-limiting HBV-infected individuals
 
985 Chinese cases
 
allele frequencies
 
allele P values
 
analyzed
 
chronic hepatitis B virus
 
genotype
 
Han Chinese population
 
interferon regulatory factors
 
Multiplex SNaPshot technique
 
odds ratio
 
patients
 
significant genotype/allele associations
 
statistically significant differences
 
tag single nucleotide polymorphisms
 
tagSNPs
 
three SNPs
 
three tagSNPs
 

Fang Yan