Article

Serum NT-proCNP concentrations are elevated in patients with chronic liver diseases and associated with complications and unfavorable prognosis of cirrhosis.

Department of Medicine III, RWTH-University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany.
Clinical biochemistry (impact factor: 2.02). 01/2012; 45(6):429-35. DOI:10.1016/j.clinbiochem.2012.01.009 pp.429-35
Source: PubMed

ABSTRACT C-type natriuretic peptide (CNP) might be an important regulator of vasodilatation, fluid and sodium balance in liver cirrhosis. We aimed at assessing its regulation and prognostic relevance in liver disease patients.
We analyzed NT-proCNP serum levels in 193 patients with chronic liver diseases and 43 healthy controls.
Serum NT-proCNP concentrations were significantly elevated in liver disease patients compared to healthy controls, with highest levels in established hepatic cirrhosis, independent of disease etiology. NT-proCNP was associated with complications of liver diseases and portal hypertension, namely ascites, esophageal varices and hepatic encephalopathy. Circulating NT-proCNP correlated inversely with renal function. Importantly, elevated NT-proCNP levels were identified as a predictor of mortality or necessity for transplantation. NT-proCNP levels >2 pmol/L indicated adverse prognosis (sensitivity 66.7%, specificity 72.8%, RR 5.4 [95%-CI 2.6-11.2]).
Serum NT-proCNP is elevated in advanced liver diseases and has prognostic value in cirrhotic patients.

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    Susanne Drechsler, Katrin Weixelbaumer, Pierre Raeven, Mohammad Jafarmadar, Anna Khadem, Martijn van Griensven, Soheyl Bahrami, Marcin Filip Osuchowski
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Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

43 healthy controls
 
adverse prognosis
 
C-type natriuretic peptide
 
chronic liver diseases
 
Circulating NT-proCNP correlated
 
hepatic cirrhosis
 
hepatic encephalopathy
 
liver cirrhosis
 
liver disease patients
 
liver diseases
 
NT-proCNP
 
NT-proCNP levels
 
NT-proCNP levels >2 pmol/L
 
portal hypertension
 
prognostic relevance
 
regulator
 
renal function
 
Serum NT-proCNP
 
Serum NT-proCNP concentrations
 
sodium balance