Quality of Life Measures for Acne Patients
Department of Dermatology, Center for Dermatology Research, Wake Forest School of Medicine, Box 2473, Medical Center Boulevard, Winston-Salem, NC 27157-1071, USA. Dermatologic clinics
(Impact Factor: 1.69).
04/2012; 30(2):293-300, ix. DOI: 10.1016/j.det.2011.11.001
Acne vulgaris affects most adolescents and two-thirds of adults and is associated with substantial psychosocial burden. Health-related quality of life (HRQOL) for patients with acne is an important factor of patient care, and several dermatologic and acne-specific measures have been created to assist in acne research, management, and care. This review describes several skin disease and acne-specific HRQOL measures and their applications in clinical care or research. The ideal HRQOL measure for the management of patients with acne is a concise questionnaire that places minimal burden on respondents and allows physicians to track improvement in HRQOL with successful treatment.
Available from: PubMed Central
- "It has been clearly shown that acne patients with poor facial skin have reduced quality of life with regard to dissatisfaction about appearance, social bother and even co-morbid depression. It has also been stressed that assessment of quality of life in studies testing any type of agent for facial acne lesions is important and strongly correlates with treatment success [19, 20]. "
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ABSTRACT: The purpose of this study was to determine the safety, tolerability and effectiveness of daily administration of an orally administered pantothenic acid-based dietary supplement in men and women with facial acne lesions.
A randomized, double-blind, placebo-controlled study of adults previously diagnosed with mild to moderate acne vulgaris was performed. Subjects were randomized to the study agent, a pantothenic acid-based dietary supplement, or a placebo for 12 weeks (endpoint). The primary outcome of the study was the difference in total lesion count between the study agent group versus the placebo group from baseline to endpoint. Secondary measurements included differences in mean non-inflammatory and inflammatory lesions, Investigators Global Assessment and Dermatology Life Quality Index (DLQI) scores between the two groups. Investigator assessment of overall improvement and skin photographs were also taken. Safety and tolerability endpoints were the assessment of adverse events and measurement of serum complete blood count and hepatic function.
Forty-eight subjects were enrolled and 41 were evaluable. There was a significant mean reduction in total lesion count in the pantothenic acid group versus placebo at week 12 (P = 0.0197). Mean reduction in inflammatory lesions was also significantly reduced and DLQI scores were significantly lower at week 12 in the pantothenic acid group versus placebo. The study agent was safe and well tolerated.
The results from this study indicate that the administration of a pantothenic acid-based dietary supplement in healthy adults with facial acne lesions is safe, well tolerated and reduced total facial lesion count versus placebo after 12 weeks of administration. Secondary analysis shows that the study agent significantly reduced area-specific and inflammatory blemishes. Further randomized, placebo-controlled trials are warranted.
05/2014; 4(1). DOI:10.1007/s13555-014-0052-3
Available from: Gregor B E Jemec
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ABSTRACT: In 2002, a comprehensive methodological review of the acne literature over 50 years revealed great variation in severity assessment and outcome measures. The authors suggested a number of possible methodological improvements, since such variation makes comparisons across the literature difficult and hampers the development of evidence-based medicine in the field. To investigate whether any improvement has been achieved, we evaluated the recent literature on topical and systemic therapeutic interventions. In 18 papers, published in 2011, we identified 25 ways of reporting changes in lesion counts and 25 ways of reporting changes in assessed grade. Fourteen grading systems were used to evaluate the therapeutic response. Only three studies reported data on quality of life. Our finding reveals a continued and substantial variation in severity assessment and outcome measurement in the acne literature.
09/2012; 1(3). DOI:10.1007/s13671-012-0016-8
BMJ (online) 05/2013; 346(may08 1):f2634. DOI:10.1136/bmj.f2634 · 17.45 Impact Factor
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