Black-blood Steady-State Free Precession (SSFP) coronary wall MRI for cardiac allografts: A feasibility study

Department of Radiology, Northwestern University, Chicago, Illinois, USA.
Journal of Magnetic Resonance Imaging (Impact Factor: 3.21). 05/2012; 35(5):1210-5. DOI: 10.1002/jmri.23543
Source: PubMed


To assess the hypothesis that steady-state free procession (SSFP) allows for imaging of the coronary wall under the conditions of fast heart rate in heart transplantation (HTx) patients.
With the approval of our Institutional Review Board, 28 HTx patients were scanned with a 1.5T scanner. Cross-sectional black-blood images of the proximal portions of the left main artery, left anterior descending artery, and right coronary artery were acquired with both a 2D, double inversion recovery (DIR) prepared turbo (fast) spin echo (TSE) sequence and a 2D DIR SSFP sequence. Image quality (scored 0-3), vessel wall area, thickness, signal-to-noise ratio (SNR, vessel wall), and contrast-to-noise ratio (CNR, wall-lumen) were compared between TSE and SSFP.
The overall image quality of SSFP was higher than TSE (1.23 ± 0.95 vs. 0.88 ± 0.69, P < 0.001). SSFP had a higher coronary wall SNR (20.1 ± 8.5 vs. 14.9 ± 4.8, P < 0.001) and wall-lumen CNR (8.2 ± 4.6 vs. 6.8 ± 3.7, P = 0.005) than TSE.
Black-blood SSFP coronary wall MRI provides higher image quality, SNR, and CNR than traditional TSE does in HTx recipients. It has the potential to become an alternative means to noninvasive imaging of cardiac allografts.

36 Reads
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: The aim of the present study was to assess the incremental benefit of compensating asynchronous cardiac quiescence in coronary wall MR imaging. With the approval of IRB, black-blood coronary wall MR imaging was performed on 30 older subjects (90 coronary wall segments). For round 1 coronary wall MR imaging, acquisition windows were traditionally set within rest period4-chamber. Totally 51 of 90 images were ranked as "good" images and resulted in an interpretability rate of 57 %. Then, an additional cine-MR was centered at coronary segments to obtain rest periodcross-sectional. The rest periodoverlap (the intersection between rest period4-chamber and rest periodcross-sectional) was measured for each coronary segment. The "good" images had a longer rest periodoverlap and higher acquisition coincidence rate (the percentage of acquisition window covered by the rest periodoverlap) than "poor" images. Coronary wall rescans (round 2) were completed at 39 coronary segments that were judged as having "poor" images in round 1 scans. The acquisition window was set within the rest periodoverlap. For the round 2 images, 17 of 39 (44 %) coronary segments were ranked as "good" images. The overall interpretability rate (68 of 90, 76 %) was significantly higher than that of the round 1 images alone. Our data demonstrated that asynchronous cardiac quiescence adversely affects the performance of coronary wall MR imaging. Individualizing acquisition windows based on multi-plane cine-MR helps to compensate for this motion discrepancy and to improve image quality.
    The international journal of cardiovascular imaging 10/2013; 30(1). DOI:10.1007/s10554-013-0318-3 · 1.81 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Objective: To test the hypothesis that biomechanical changes are quantitatively related to morphological features of coronary arteries in heart transplant (HTx) recipients. Materials and methods: With IRB approval, three-dimensional (3D) magnetic resonance (MR) angiography and two-dimensional (2D) black-blood stead-state free precession (SSFP) MR imaging were performed to image coronary arteries of 36 HTx patients. Contours of coronary wall were manually drawn. For each coronary segment, coronary wall thickness, wall area, lumen area (in systole and diastole) were acquired. Coronary distensibility index (CDI) and the percent of the coronary wall occupying the vessel area (PWOV) were calculated. Results: There are totally 98 coronary segments eligible for quantitative analysis from 27 HTx patients. The CDI is 4.90 ± 2.44 mmHg(-1). The mean wall thickness is 1.49 ± 0.24 mm and the PWOV is 74.6% ± 7.5%. CDI has moderate correlations with wall thickness (r=-0.531, P<0.001) and with PWOV (R=-0.435, P<0.001). Conclusions: Detected with coronary MR imaging, CDI is quantitatively correlated with the morphological features of the coronary artery in HTx patients. Coronary stiffness has the potential to become an alternative imaging biomarker for the quantitative assessment of the status of cardiac allografts.
    European Journal of Radiology 05/2014; 83(8). DOI:10.1016/j.ejrad.2014.05.028 · 2.37 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: The aim of the present study was to determine the effects of the latency period on the performance of free-breathing coronary wall MRI. With the approval of IRB, 70 participants were recruited for coronary wall magnetic resonance imaging (MRI) and provided written informed consent. In 35 subjects, right coronary segments (RCA1–3) were imaged first; in the remaining subjects, the left coronary segments (LM and LAD1–3) were imaged first. The images were classified into groups; group 1 contained right coronary images from the subjects whose right coronary segments were imaged first and left coronary images from the subjects whose left coronary segments were imaged first. Group 2 contained the other coronary segments. The image scores (ranked1–3), latency periods, drift of the position of the navigator (NAV), scan efficiency were compared between image groups. Image group 1 has higher scores (1.66 ± 0.55 vs. 1.46 ± 0.51), shorter latency periods (32.04 ± 4.24 vs. 44.22 ± 5.57 min), lower drift in the location of the NAV (1.90 ± 1.27 mm vs. 2.61 ± 1.71 mm) and higher scan efficiency (32.7 ± 7.6 vs. 29.9 ± 7.9 %) than group 2. Long latency periods have a significantly negative impact on the image quality of coronary wall MRI.
    The International Journal of Cardiovascular Imaging 01/2015; 31(3). DOI:10.1007/s10554-014-0586-6 · 1.81 Impact Factor
Show more