Article

Caspase-1 and-3 Inhibiting Drimane Sesquiterpenoids from the Extremophilic Fungus Penicillium solitum

Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, Montana 59812, USA.
Journal of Natural Products (Impact Factor: 3.95). 02/2012; 75(2):262-6. DOI: 10.1021/np200528n
Source: PubMed

ABSTRACT Two new drimane sesquiterpene lactones and one new tricarboxylic acid derivative were isolated from the Berkeley Pit extremophilic fungus Penicillium solitum. The structures of these compounds were deduced by spectroscopic analysis. Berkedrimanes A and B inhibited the signal transduction enzymes caspase-1 and caspase-3 and mitigated the production of interleukin 1-β in the induced THP-1 (pro-monocytic leukemia cell line) assay.

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