Treatment rather than avoidance may be within reach for children with food allergies.

JAMA The Journal of the American Medical Association (Impact Factor: 35.29). 01/2012; 307(4):345-6, 348. DOI: 10.1001/jama.2012.32
Source: PubMed
5 Reads

  • Current Opinion in Allergy and Clinical Immunology 04/2012; 12(3):269-70. DOI:10.1097/ACI.0b013e3283535a54 · 3.57 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: This article is the result of consensus reached by a working group of clinical experts in paediatric allergology as well as representatives from an ethical committee and the European Medicine Agency (EMA). The manuscript covers clinical, scientific, regulatory and ethical perspectives on allergen-specific immunotherapy in childhood. Unmet needs are identified. To fill the gaps and to bridge the different points of view, recommendations are made to researchers, to scientific and patient organizations and to regulators and ethical committees. Working together for the benefit of the community is essential. The European Academy of Allergy and Clinical Immunology (EAACI) serves as the platform of such cooperation.
    Pediatric Allergy and Immunology 06/2012; 23(4):300-6. DOI:10.1111/j.1399-3038.2012.01313.x · 3.40 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: During the last decades the prevalence of food allergies has significantly increased among children and antigen avoidance still remains the standard care for the management of this condition. Most reactions are IgE-mediated with a high risk of anaphylaxis requiring emergency medications in case of inadvertent ingestion. Recent studies showed that continuous administration of the offending food, rather than an elimination diet, could promote the development and maintenance of oral tolerance. Indeed, intestinal transit of food proteins and their interaction with gut-associated lymphoid tissue (GALT) is the essential prerequisite for oral tolerance. On the contrary, low-dose cutaneous exposure to environmental foods in children with atopic dermatitis and altered skin barrier facilitates allergic sensitization. The timing and the amount of cutaneous and oral exposure determine whether a child will have allergy or tolerance. Furthermore, previous preventive strategies such as the elimination diet during pregnancy and breastfeeding, prolonged exclusive breastfeeding and delayed weaning to solid foods did not succeed in preventing the development of food allergy. On the other hand, there could be an early narrow window of immunological opportunity to expose children to allergenic foods and induce natural tolerance. Finally, the gradual exposure to the offending food through special protocols of specific oral tolerance induction (SOTI) may be a promising approach to a proactive treatment of food allergy.
    Current pharmaceutical design 06/2012; 18(35). DOI:10.2174/138161212803530772 · 3.45 Impact Factor