Article

Association of Lifetime Cognitive Engagement and Low β-Amyloid Deposition.

and Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois (Dr Wilson).
Archives of neurology (Impact Factor: 7.01). 01/2012; 69(5). DOI: 10.1001/archneurol.2011.2748
Source: PubMed

ABSTRACT OBJECTIVE: To assess the association between lifestyle practices (cognitive and physical activity) and β-amyloid deposition, measured with positron emission tomography using carbon 11-labeled Pittsburgh Compound B ([(11)C]PiB), in healthy older individuals. DESIGN: Cross-sectional clinical study. SETTING: Berkeley, California. PARTICIPANTS: Volunteer sample of 65 healthy older individuals (mean age, 76.1 years), 10 patients with Alzheimer disease (AD) (mean age, 74.8 years), and 11 young controls (mean age, 24.5 years) were studied from October 31, 2005, to February 22, 2011. MAIN OUTCOME MEASURES: Cortical [(11)C]PiB average (frontal, parietal, lateral temporal, and cingulate regions) and retrospective, self-report scales assessing participation in cognitive activities (eg, reading, writing, and playing games) and physical exercise. RESULTS: Greater participation in cognitively stimulating activities across the lifespan, but particularly in early and middle life, was associated with reduced [(11)C]PiB uptake (P < .001, accounting for age, sex, and years of education). Older participants in the highest cognitive activity tertile had [(11)C]PiB uptake comparable to young controls, whereas those in the lowest cognitive activity tertile had [(11)C]PiB uptake comparable to patients with AD. Although greater cognitive activity was associated with greater physical exercise, exercise was not associated with [(11)C]PiB uptake. CONCLUSIONS: Individuals with greater early- and middle- life cognitive activity had lower [(11)C]PiB uptake. The tendency to participate in cognitively stimulating activities is likely related to engagement in a variety of lifestyle practices that have been implicated in other studies showing reduced risk of AD-related pathology. We report a direct association between cognitive activity and [(11)C]PiB uptake, suggesting that lifestyle factors found in individuals with high cognitive engagement may prevent or slow deposition of β-amyloid, perhaps influencing the onset and progression of AD.

1 Follower
 · 
199 Views
  • [Show abstract] [Hide abstract]
    ABSTRACT: As the field begins to test the concept of a “preclinical” stage of neurodegenerative disease, when the pathophysiological process has begun in the brain, but clinical symptoms are not yet manifest, a number of intriguing questions have already arisen. In particular, in preclinical Alzheimer’s disease (AD), the temporal relationship of amyloid markers to markers of neurodegeneration and their relative utility in the prediction of cognitive decline among clinically normal older individuals remains to be fully elucidated. Secondary prevention trials in AD have already begun in both genetic at-risk and amyloid at-risk cohorts, with several more trials in the planning stages, and should provide critical answers about whether intervention at this very early stage of disease can truly bend the curve of clinical progression. This review will highlight recent progress in cognitive, imaging, and biomarker outcomes in the field of preclinical AD, and the remaining gaps in knowledge.
    Neuron 11/2014; 84(3). DOI:10.1016/j.neuron.2014.10.038 · 15.98 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: This study examined cognitive activity engagement, depression, executive functioning, and memory in a sample of older adults. Participants were assessed at baseline and 15 months later. Depression and activity level were significantly correlated at baseline, such that increased depressive symptoms were associated with decreased cognitive activity. Higher baseline activity scores, particularly on a measure of participation in cognitively challenging activities, predicted higher scores on memory and executive functioning tests at follow up. Findings highlight the benefits of activity engagement in later life, such that activity engagement is associated with reduced cognitive decline in older adults.
    Activities Adaptation & Aging 07/2013; 37(3):251-264. DOI:10.1080/01924788.2013.816833
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: This article develops a new model for understanding the aging experience. Drawing upon aging literature from the chronological, biological, mental, and social aging perspectives, the model offered is an integrated perspective that provides better understanding of the relationship between chronological age and an individual's perceived age. The article provides evidence of ways that consumers are trying to "time bend" and change today's perceived reality of aging. The article concludes with a discussion of implications for the health care industry and provides examples of how some businesses seem to already be looking at aging and health related issues through this lens.
    Health Marketing Quarterly 11/2014; 31(4):383-98. DOI:10.1080/07359683.2014.966010