Erratum to “A critical review of the influence of oxytocin nasal spray on social cognition in humans: Evidence and future directions” [Horm. Behav. 61 (2012) 410–418]

Brain & Mind Research Institute, University of Sydney, 2050, Australia.
Hormones and Behavior (Impact Factor: 4.63). 01/2012; 61(3):410-8. DOI: 10.1016/j.yhbeh.2012.01.002
Source: PubMed


The past eight years of research has demonstrated that oxytocin nasal spray has a significant impact on human social cognition. The aim of this review is to provide critical comment on the literature using an information-processing framework. We provide a summary of fundamental assumptions of information-processing models and highlight an impressive range of consistent findings that demonstrate the impact of oxytocin nasal spray on social information processing. These findings include that oxytocin nasal spray improves the early conceptual detection of affect from social cues and improves the accurate appraisal of affect from social cues at elaborate and strategic levels of processing. There is some evidence that these effects may be particularly powerful for positive social cues. This review comments on inconsistent results that have been reported. We argue that such inconsistencies can, in part, be explained by variability across experiments in the degree to which potential extraneous confounds have been controlled, the different methods upon which studies assessed cognition, and the extent to which the focus of investigation has been on group-based outcomes. Finally, we argue that sound cognitive experimental methods can provide powerful tools to identify markers of response to oxytocin nasal spray that can be integrated into more complex circuitry models. The identification of robust markers has particular value in predicting behavioral and therapeutic response to intervention. This should now be a major focus for future research. This article is part of a Special Issue entitled Oxytocin, Vasopressin, and Social Behavior.

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Available from: Adam J Guastella, Mar 21, 2014
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    • "Furthermore, infants express more social behavior(s) in face-to-face interactions when their father receives intranasal OXT than when their father receives placebo, and experience a post-interaction increase in salivary OXT (Weisman et al., 2012). Moreover, intranasal OXT appears to influence several features of social cognition (e.g., face/emotion recognition, judgments of trustworthiness and attractiveness; Graustella and MacLeod, 2012; van IJzendoorn and Bakermans-Kranenburg, 2012). However, these studies on adults examined whether OXT influenced perceptions of other individuals' attractiveness. "
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    Frontiers in Behavioral Neuroscience 10/2015; 9. DOI:10.3389/fnbeh.2015.00251 · 3.27 Impact Factor
    • "The oxytocin network has been widely studied for its role in prosocial behaviors in animals (Lim and Young, 2006) and humans (for reviews: Bartz et al., 2011; Guastella and MacLeod, 2012). More precisely, experiments in humans have shown using intranasal oxytocin administration, that this neuropeptide is associated with social cognitive processes such as mental-state attribution (i.e. "
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    • "Finally, it would be useful to identify reliable markers of response to oxytocin in different clinical populations, to be able to predict who is receiving adequate dosing and likely to respond to treatment (Guastella and MacLeod, 2012). Currently, there is little understanding as to what constitutes a reliable response to oxytocin, although some social cognitive tests, such as emotion recognition, have shown promise as potential markers in healthy populations (Guastella and MacLeod, 2012; Shahrestani et al., 2013). Thus, the aim of this study was to further explore the different domains of social cognition in patients with schizophrenia following intranasal administration of oxytocin. "
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