Erratum to “A critical review of the influence of oxytocin nasal spray on social cognition in humans: Evidence and future directions” [Horm. Behav. 61 (2012) 410–418]
Brain & Mind Research Institute, University of Sydney, 2050, Australia.Hormones and Behavior (Impact Factor: 4.63). 01/2012; 61(3):410-8. DOI: 10.1016/j.yhbeh.2012.01.002
The past eight years of research has demonstrated that oxytocin nasal spray has a significant impact on human social cognition. The aim of this review is to provide critical comment on the literature using an information-processing framework. We provide a summary of fundamental assumptions of information-processing models and highlight an impressive range of consistent findings that demonstrate the impact of oxytocin nasal spray on social information processing. These findings include that oxytocin nasal spray improves the early conceptual detection of affect from social cues and improves the accurate appraisal of affect from social cues at elaborate and strategic levels of processing. There is some evidence that these effects may be particularly powerful for positive social cues. This review comments on inconsistent results that have been reported. We argue that such inconsistencies can, in part, be explained by variability across experiments in the degree to which potential extraneous confounds have been controlled, the different methods upon which studies assessed cognition, and the extent to which the focus of investigation has been on group-based outcomes. Finally, we argue that sound cognitive experimental methods can provide powerful tools to identify markers of response to oxytocin nasal spray that can be integrated into more complex circuitry models. The identification of robust markers has particular value in predicting behavioral and therapeutic response to intervention. This should now be a major focus for future research. This article is part of a Special Issue entitled Oxytocin, Vasopressin, and Social Behavior.
Full-textDOI: · Available from: Adam J Guastella, Mar 21, 2014
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- "The oxytocin network has been widely studied for its role in prosocial behaviors in animals (Lim and Young, 2006) and humans (for reviews: Bartz et al., 2011; Guastella and MacLeod, 2012). More precisely, experiments in humans have shown using intranasal oxytocin administration, that this neuropeptide is associated with social cognitive processes such as mental-state attribution (i.e. "
ABSTRACT: Emotion perception has been extensively studied in cognitive neurosciences and stands as a promising intermediate phenotype of social cognitive processes and psychopathologies. Exciting imaging genetic studies have recently identified genetic and epigenetic variants affecting brain responses during emotion perception tasks, but characterizing how these variants interact and relate to higher-order cognitive processes remains a challenge. Here, we integrate works in parallel fields and propose a new psychophysical conceptualization to address this issue. This approach proposes to consider genetic variants as 'filters' of perceptual information that can interact to shape different perceptual profiles. Importantly, these perceptual profiles can be precisely described and compared between multivariate genetic groups using a new psychophysical method. Crucially, this approach represents a potentially powerful novel tool to address gene-by-gene and gene-by-environment interactions, and provides a new cognitive perspective to link social perceptive and social cognitive processes in the context of psychiatric disorders.Psychiatric genetics 10/2015; 25(5):216-22. DOI:10.1097/YPG.0000000000000102 · 1.94 Impact Factor
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- "Finally, it would be useful to identify reliable markers of response to oxytocin in different clinical populations, to be able to predict who is receiving adequate dosing and likely to respond to treatment (Guastella and MacLeod, 2012). Currently, there is little understanding as to what constitutes a reliable response to oxytocin, although some social cognitive tests, such as emotion recognition, have shown promise as potential markers in healthy populations (Guastella and MacLeod, 2012; Shahrestani et al., 2013). Thus, the aim of this study was to further explore the different domains of social cognition in patients with schizophrenia following intranasal administration of oxytocin. "
ABSTRACT: Schizophrenia is associated with significant impairments in both higher and lower order social cognitive performance and these impairments contribute to poor social functioning. People with schizophrenia report poor social functioning to be one of their greatest unmet treatment needs. Recent studies have suggested the potential of oxytocin as such a treatment, but mixed results render it uncertain what aspects of social cognition are improved by oxytocin and, subsequently, how oxytocin might best be applied as a therapeutic. The aim of this study was to determine whether a single dose of oxytocin improved higher-order and lower-order social cognition performance for patients with schizophrenia across a well-established battery of social cognition tests. Twenty-one male patients received both a single dose of oxytocin nasal spray (24IU) and a placebo, two weeks apart in a randomized within-subjects placebo controlled design. Following each administration, participants completed the social cognition tasks, as well as a test of general neurocognition. Results revealed that oxytocin particularly enhanced performance on higher order social cognition tasks, with no effects on general neurocognition. Results for individual tasks showed most improvement on tests measuring appreciation of indirect hints and recognition of social faux pas. These results suggest that oxytocin, if combined to enhance social cognition learning, may be beneficial when targeted at higher order social cognition domains. This study also suggests that these higher order tasks, which assess social cognitive processing in a social communication context, may provide useful markers of response to oxytocin in schizophrenia. Copyright © 2015 Elsevier B.V. All rights reserved.Schizophrenia Research 07/2015; DOI:10.1016/j.schres.2015.06.005 · 3.92 Impact Factor
Brain 03/2015; 138(7). DOI:10.1093/brain/awv060 · 9.20 Impact Factor
- "Several studies have suggested that oxytocin has therapeutic effects on autistic deficits in social responses and the understanding of emotion in others (Andari et al., 2010; Striepens et al., 2012). More generally, literature on human and non-human primates presents converging evidence of oxytocin's positive effects on prosocial behaviour (Guastela and MacLeod, 2012; Chang and Platt, 2014). Recently, 7-to 14-day-old macaques where found to increase their facial gesturing at a human caregiver after oxytocin nebulization (Simpson et al., 2014). "