Article

Prevalence of 16S rRNA methylase genes in Enterobacteriaceae isolates from a Greek university hospital.

4th Department of Internal Medicine, Infectious Disease Laboratory, Molecular Biology Section, Athens University School of Medicine, Chaidari, Greece.
Clinical Microbiology and Infection (impact factor: 4.54). 03/2012; 18(3):E52-4. DOI:10.1111/j.1469-0691.2011.03738.x pp.E52-4
Source: PubMed

ABSTRACT 16S ribosomal RNA methylase-mediated high-level resistance to 4-,6-aminoglycosides has been reported in clinical isolates of gram-negative bacilli from several countries. Three of 1534 (0.2%) isolates of Klebsiella pneumoniae and three of 734 (0.4%) Proteus mirabilis isolates from a university hospital in Athens, Greece, were positive for rmtB and highly resistant to all aminoglycosides tested (MICs ≥256 mg/L). Two of the K. pneumoniae rmtB-bearing isolates, were KPC-2 and OXA-10 producers and the third was a DHA-1 producer. One of the P. mirabilis isolates was a VIM-1 and OXA-10 producer and one was an OXA-10 producer. All rmtB-harbouring isolates were clonally unrelated. None of the E. coli (n = 1398) and Enterobacter spp. (n = 414) isolates were positive for armA, rmtA, rmtB, rmtC or rmtD.

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Keywords

16S ribosomal RNA methylase-mediated high-level resistance
 
aminoglycosides
 
countries
 
DHA-1 producer
 
E. coli
 
Greece
 
K. pneumoniae rmtB-bearing
 
Klebsiella pneumoniae
 
KPC-2
 
P. mirabilis
 
rmtB
 
rmtB-harbouring
 
rmtD
 
university hospital