Article
Surgery for Pulmonary Sclerosing Hemangioma: Lobectomy versus Limited Resection.
Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Korea.
The Korean journal of thoracic and cardiovascular surgery
02/2011;
44(1):39-43.
DOI:10.5090/kjtcs.2011.44.1.39
pp.39-43
Source: PubMed
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Article: Therapeutic equivalence of three metered-dose inhalers containing salbutamol (Albuterol) in protecting against methacholine-induced bronchoconstriction in children with asthma.
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ABSTRACT: Many pharmaceutical companies sell salbutamol in metered-dose inhalers (MDI) for the treatment of asthma. However, the therapeutic equivalence of the more recently released generic products has not been compared with the original patented product in children. Twenty children with mild to moderate asthma, presently asymptomatic and with normal lung function, were randomly allocated to receive 200 microg of inhaled salbutamol (Albuterol) from three MDIs prepared by different manufacturers: the original Glaxo product and two generic products. The three drug formulations and placebo were given 10 min before a methacholine challenge test to determine the degree of protection provided against methacholine-induced bronchoconstriction (MIB) by each salbutamol aerosol. Tests were performed on 4 consecutive days. Doubling concentrations of methacholine were inhaled until the forced expired volume in 1 sec (FEV(1)) decreased by 20% from its baseline value. Compared to placebo, all patients increased significantly the provocation concentration that decreased FEV(1) by 20% (PC(20)) by more than one doubling concentration after inhaling each of the three salbutamol aerosols. The effectiveness was not significantly different between medications (P = 0.8). There was a small but significant difference among MDIs in aerosol particle size and total and fine-particle dose released per actuation. However, no relation was found between aerosol particle size or released dose and the protective effect. This study shows that the three tested brands of salbutamol MDI protected asthmatic children equally from MIB. When prescribing these salbutamol MDIs to prevent symptoms triggered by nonspecific stimuli in asthmatic children, the selection may be based on cost-benefit criteria.Pediatric Pulmonology 01/2002; 32(6):447-52. · 2.53 Impact Factor
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Keywords
21 patients
9 patients
limited resection group
lobectomy group
Lymph node dissection
lymph node metastasis
mean follow-up duration
mean hospital
Medical records
patient's characteristics
patients
postoperative complication
rare thoracic tumor
standard operative procedure
sufficient resection margin
surgical outcome comparable
surgical resection
tumor-related
two groups
Video-assisted thoracoscopic surgery