Article

A waveform independent cell identification method to study long-term variability of spike recordings.

Trinity Centre for Bioengineering and Trinity College Institute of Neuroscience, Trinity College Dublin, Ireland.
Conference proceedings: ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 08/2011; 2011:2558-61. DOI:10.1109/IEMBS.2011.6090707 pp.2558-61
Source: PubMed

ABSTRACT Extracellular potential recordings are important in neuroscience; however the variability of spike waveforms has not been extensively studied to date. This study examines the variability of spike recordings within and between sessions. Place cell recordings were used in order to identify the cells across successive sessions. Place cells allow neuron spike recordings to be identified across different sessions using place fields, which are independent of the cell's spike waveform. The results show that the distribution of the residues within a session does not follow a normal distribution, a t-distribution is more suitable. The results also show that the amplitude of the spikes can vary largely between successive sessions (up to 47%), this is an important factor to be considered in long term spike recording systems.

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Keywords

cell's spike waveform
 
Extracellular potential recordings
 
neuron spike recordings
 
neuroscience
 
normal distribution
 
Place cell recordings
 
Place cells
 
place fields
 
spike recordings
 
spike waveforms
 
spikes
 
study examines
 
t-distribution
 
term spike recording systems