Machine-learning techniques have found widespread applications in bioinformatics. Such techniques provide invaluable insight on understanding the complex biomedical mechanisms and predicting the optimal individualized intervention for patients. In our case, we are particularly interested in developing an individualized clinical guideline on wheelchair tilt and recline usage for people with spinal cord injury (SCI). The current clinical practice suggests uniform settings to all patients. However, our previous study revealed that the response of skin blood flow to wheelchair tilt and recline settings varied largely among patients. Our finding suggests that an individualized setting is needed for people with SCI to maximally utilize the residual neurological function to reduce pressure ulcer risk. In order to achieve this goal, we intend to develop an intelligent model to determine the favorable wheelchair usage to reduce pressure ulcers risk for wheelchair users with SCI. In this study, we use artificial neural networks (ANNs) to construct an intelligent model that can predict whether a given tilt and recline setting will be favorable to people with SCI based on neurological functions and SCI injury history. Our results indicate that the intelligent model significantly outperforms the traditional statistical approach in accurately classifying favorable wheelchair tilt and recline settings. To the best of our knowledge, this is the first study using intelligent models to predict the favorable wheelchair tilt and recline angles. Our methods demonstrate the feasibility of using ANN to develop individualized wheelchair tilt and recline guidance for people with SCI.
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"It has been pointed out that the electronic nose is a simple, quick and real-time monitoring system  and is a very good statistical tool for many numeric as well as nonnumeric calculations. Specifically, ANNs are known to be a powerful tool to simulate various non-linear systems and have been applied to numerous problems of considerable complexity in many fields, including engineering , psychology, medicinal chemistry  , diagnostics  ,and pharmaceutical research . "
[Show description][Hide description] DESCRIPTION: Abstract: The present paper highlights the low cost and rapid performance system to determine the freshness of papaya using an electronic nose. Various gases produced by the non-destructive papaya are alcohol, methane (CH4) and carbon monoxide (CO). The concentrations of these gases were detected and
determined by an array of gas sensors. In actual, the freshness studies were carried out by measuring the
concentration of the alcohol, methane and carbon monoxide gases as a function of the time pertaining to
status of the papaya. The system displays results using LabVIEW software and developed GUI. The studies are useful as a basic foundation design and making an economical practical detector system testing for freshness of papaya.
"It is a very good statistical tool for many numeric as well as nonnumeric calculations. Specifically, ANNs are known to be a powerful tool to simulate various non-linear systems and have been applied to numerous problems of considerable complexity in many fields, including engineering , psychology, medicinal chemistry  , diagnostics  , and pharmaceutical research  "
[Show abstract][Hide abstract] ABSTRACT: Artificial neural networks (ANNs) technology models the pattern recognition capabilities of the neural networks of the brain. Similarly to a single neuron in the brain, artificial neuron unit receives inputs from many external sources, processes them, and makes decisions. Interestingly, ANN simulates the biological nervous system and draws on analogues of adaptive biological neurons. ANNs do not require rigidly structured experimental designs and can map functions using historical or incomplete data, which makes them a powerful tool for simulation of various non-linear systems.ANNs have many applications in various fields, including engineering, psychology, medicinal chemistry and pharmaceutical research. Because of their capacity for making predictions, pattern recognition, and modeling, ANNs have been very useful in many aspects of pharmaceutical research including modeling of the brain neural network, analytical data analysis, drug modeling, protein structure and function, dosage optimization and manufacturing, pharmacokinetics and pharmacodynamics modeling, and in vitro in vivo correlations. This review discusses the applications of ANNs in drug delivery and pharmacological research.
The Open Bioinformatics Journal 01/2013; 7(1):49-62.
[Show abstract][Hide abstract] ABSTRACT: People with spinal cord injury (SCI) are at risk for pressure ulcers because of their poor motor function and consequent prolonged sitting in wheelchairs. The current clinical practice typically uses the wheelchair tilt and recline to attain specific seating angles (sitting postures) to reduce seating pressure in order to prevent pressure ulcers. The rationale is to allow the development of reactive hyperemia to re-perfuse the ischemic tissues. However, our study reveals that a particular tilt and recline setting may result in a significant increase of skin perfusion for one person with SCI, but may cause neutral or even negative effect on another person. Therefore, an individualized guidance on wheelchair tilt and recline usage is desirable in people with various levels of SCI. In this study, we intend to demonstrate the feasibility of using machine-learning techniques to classify and predict favorable wheelchair tilt and recline settings for individual wheelchair users with SCI. Specifically, we use artificial neural networks (ANNs) to classify whether a given tilt and recline setting would cause a positive, neutral, or negative skin perfusion response. The challenge, however, is that ANN is prone to over fitting, a situation in which ANN can perfectly classify the existing data while cannot correctly classify new (unseen) data. We investigate using the genetic algorithm (GA) to train ANN to reduce the chance of converging on local optima and improve the generalization capability of classifying unseen data. Our experimental results indicate that the GA-based ANN significantly improves the generalization ability and outperforms the traditional statistical approach and other commonly used classification techniques, such as BP-based ANN and support vector machine (SVM). To the best of our knowledge, there are no such intelligent systems available now. Our research fills in the gap in existing evidence.
IEEE 23rd International Conference on Tools with Artificial Intelligence, ICTAI 2011, Boca Raton, FL, USA, November 7-9, 2011; 11/2011