Article

Limited maximal flow rate of target-controlled remifentanil infusion and induced cough.

Department of Anaesthesiology and Pain Medicine, Ajou University School of Medicine, Suwon, Korea.
Anaesthesia (impact factor: 2.96). 02/2012; 67(2):145-8. DOI:10.1111/j.1365-2044.2011.06961.x pp.145-8
Source: PubMed

ABSTRACT This study evaluated the effect of limiting maximal infusion-pump flow rate on suppression of remifentanil-induced cough during target-controlled infusion. Two hundred and ten patients were randomly assigned to receive remifentanil at an effect-site concentration of 4.0 ng.ml(-1) with maximal flow rate limited to 100 (group R(100)), 200 (group R(200)), or 1200 ml.h(-1) (group R(1200)). The number of episodes of cough were recorded and graded as mild (1-2), moderate (3-4), or severe (5 or more). The incidence of cough was 2.9% in group R(100), 5.7% in group R(200) and 25.7% in group R(1200). Patients in group R(100) and R(200) had a significantly lower incidence of cough than those in group R(1200) (p < 0.05). Zero, two and five patients coughed a moderate amount in groups R(100), R(200) and group R(1200), respectively (p < 0.05). Limiting maximal infusion rate during remifentanil TCI suppressed remifentanil-induced cough.

0 0
 · 
0 Bookmarks
 · 
25 Views
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

cough
 
effect-site concentration
 
lower incidence
 
maximal flow rate limited
 
maximal infusion-pump flow rate
 
patients
 
patients coughed
 
remifentanil TCI suppressed remifentanil-induced cough
 
remifentanil-induced cough
 
severe
 

S K Min