Article

Preparation and characterization of free films of high amylose/pectin mixtures cross-linked with sodium trimetaphosphate.

Graduate Program in Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, São Paulo State University-UNESP , Araraquara, SP , Brazil.
Drug Development and Industrial Pharmacy (impact factor: 1.49). 01/2012; 38(11):1354-9. DOI:10.3109/03639045.2011.650863
Source: PubMed

ABSTRACT High amylose and pectin were mixed at 1:1 mass ratio and cross-linked with sodium trimetaphosphate (STMP) in alkaline medium. Films were prepared from aqueous dispersions of these cross-linked polymer blend at three different concentrations (3, 4 and 5%), by solvent casting method. Characterization of the films included thickness, surface morphology, water uptake, water vapor permeability (WVP), tensile strength measurements and enzymatic digestion. The cross-linking allowed to obtain films with improved mechanical properties and reduced WVP. The high resistance to enzymatic digestion exhibited by these films represents a promising approach to their application in the development of colon drug delivery systems.

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Keywords

alkaline medium
 
aqueous dispersions
 
colon drug delivery systems
 
cross-linking
 
different concentrations
 
Films
 
pectin
 
promising approach
 
sodium trimetaphosphate
 
solvent
 
tensile strength measurements
 
thickness
 
water uptake
 
water vapor permeability
 

Fabíola Garavello Prezotti