Article

Multi-channel near-infrared spectroscopy shows reduced activation in the prefrontal cortex during facial expression processing in pervasive developmental disorder.

Department of Psychiatry, Course of Integrated Brain Sciences, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan.
Psychiatry and Clinical Neurosciences (impact factor: 2.13). 02/2012; 66(1):26-33. DOI:10.1111/j.1440-1819.2011.02290.x pp.26-33
Source: PubMed

ABSTRACT The purpose of the present study was to investigate whether individuals with pervasive developmental disorders (PDD) show differential activation during an emotional activation task compared with age- and sex-matched controls, by measuring changes in the concentration of oxygenated (oxyHb) and deoxygenated (deoxyHb) hemoglobin, using near-infrared spectroscopy (NIRS).
Fourteen patients with PDD and 14 age- and sex-matched healthy controls participated in the study. The relative changes of concentrations of oxyHb and deoxyHb were measured on NIRS during an implicit processing task of fearful expression using Japanese standard faces.
PDD patients had significantly reduced oxyHb changes in the prefrontal cortex (PFC) compared to healthy controls.
PFC dysfunction may exist in PDD.

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Keywords

deoxygenated
 
differential activation
 
emotional activation task
 
fearful expression
 
healthy controls
 
implicit processing task
 
Japanese standard
 
near-infrared spectroscopy
 
oxygenated
 
oxyHb changes
 
patients
 
PDD
 
PDD patients
 
pervasive developmental disorders
 
PFC dysfunction
 
prefrontal cortex
 
relative changes
 
sex-matched controls
 
sex-matched healthy controls
 

Yoshihiro Nakadoi