Article

Cardiovascular Risk Assessment with Vascular Function, Carotid Atherosclerosis and the UKPDS Risk Engine in Korean Patients with Newly Diagnosed Type 2 Diabetes.

Department of Internal Medicine, Eulji University School of Medicine, Seoul, Korea.
Diabetes & metabolism journal 12/2011; 35(6):619-27. DOI:10.4093/dmj.2011.35.6.619 pp.619-27
Source: PubMed

ABSTRACT Patients with type 2 diabetes have an increased risk of cardiovascular disease. Few studies have evaluated the cardiovascular disease (CVD) risk simultaneously using the United Kingdom Prospective Diabetes Study (UKPDS) risk engine and non-invasive vascular tests in patients with newly diagnosed type 2 diabetes.
Participants (n=380; aged 20 to 81 years) with newly diagnosed type 2 diabetes were free of clinical evidence of CVD. The 10-year coronary heart disease (CHD) and stroke risks were calculated for each patient using the UKPDS risk engine. Carotid intima media thickness (CIMT), flow mediated dilation (FMD), pulse wave velocity (PWV) and augmentation index (AI) were measured. The correlations between the UKPDS risk engine and the non-invasive vascular tests were assessed using partial correlation analysis, after adjusting for age, and multiple regression analysis.
The mean 10-year CHD and 10-year stroke risks were 14.92±11.53% and 4.03±3.95%, respectively. The 10-year CHD risk correlated with CIMT (P<0.001), FMD (P=0.017), and PWV (P=0.35) after adjusting for age. The 10-year stroke risk correlated only with the mean CIMT (P<0.001) after adjusting for age. FMD correlated with age (P<0.01) and systolic blood pressure (P=0.09). CIMT correlated with age (P<0.01), HbA1c (P=0.05), and gender (P<0.01).
The CVD risk is increased at the onset of type 2 diabetes. CIMT, FMD, and PWV along with the UKPDS risk engine should be considered to evaluate cardiovascular disease risk in patients with newly diagnosed type 2 diabetes.

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Keywords

10-year coronary heart disease
 
10-year stroke risk correlated
 
10-year stroke risks
 
augmentation index
 
cardiovascular disease
 
cardiovascular disease risk
 
Carotid intima media thickness
 
clinical evidence
 
correlations
 
CVD risk
 
mean CIMT
 
multiple regression analysis
 
non-invasive vascular tests
 
partial correlation analysis
 
pulse wave velocity
 
stroke risks
 
systolic blood pressure
 
type 2 diabetes
 
UKPDS risk engine
 
United Kingdom Prospective Diabetes Study