Cardiovascular Risk Assessment with Vascular Function, Carotid Atherosclerosis and the UKPDS Risk Engine in Korean Patients with Newly Diagnosed Type 2 Diabetes

Department of Internal Medicine, Eulji University School of Medicine, Seoul, Korea.
Diabetes & metabolism journal 12/2011; 35(6):619-27. DOI: 10.4093/dmj.2011.35.6.619
Source: PubMed


Patients with type 2 diabetes have an increased risk of cardiovascular disease. Few studies have evaluated the cardiovascular disease (CVD) risk simultaneously using the United Kingdom Prospective Diabetes Study (UKPDS) risk engine and non-invasive vascular tests in patients with newly diagnosed type 2 diabetes.
Participants (n=380; aged 20 to 81 years) with newly diagnosed type 2 diabetes were free of clinical evidence of CVD. The 10-year coronary heart disease (CHD) and stroke risks were calculated for each patient using the UKPDS risk engine. Carotid intima media thickness (CIMT), flow mediated dilation (FMD), pulse wave velocity (PWV) and augmentation index (AI) were measured. The correlations between the UKPDS risk engine and the non-invasive vascular tests were assessed using partial correlation analysis, after adjusting for age, and multiple regression analysis.
The mean 10-year CHD and 10-year stroke risks were 14.92±11.53% and 4.03±3.95%, respectively. The 10-year CHD risk correlated with CIMT (P<0.001), FMD (P=0.017), and PWV (P=0.35) after adjusting for age. The 10-year stroke risk correlated only with the mean CIMT (P<0.001) after adjusting for age. FMD correlated with age (P<0.01) and systolic blood pressure (P=0.09). CIMT correlated with age (P<0.01), HbA1c (P=0.05), and gender (P<0.01).
The CVD risk is increased at the onset of type 2 diabetes. CIMT, FMD, and PWV along with the UKPDS risk engine should be considered to evaluate cardiovascular disease risk in patients with newly diagnosed type 2 diabetes.

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Available from: Bo Kyung Koo, Oct 30, 2014
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    • "One meta-analysis by Brohall et al. [31] demonstrated that patients with T2DM had a 0.13-mm thicker carotid IMT than normal participants. In a Korean study, Seon et al. [32] reported the mean carotid IMT of Korean patients newly diagnosed with T2DM was 0.67±0.15 mm. "
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    Diabetes & metabolism journal 10/2013; 37(5):365-74. DOI:10.4093/dmj.2013.37.5.365
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    • "Prediction and early diagnosis of coronary heart disease (CHD) facilitates appropriate intervention in the early stages of this disease. Despite our growing understanding of the pathophysiology of CHD in subjects with type 2 diabetes mellitus (T2D), predicting future CHD events remains largely reliant upon evaluation of traditional risk factors [1,2]. Even in apparently low- and intermediate-risk individuals assessed by conventional risk scores, a large number of diabetic subjects still experience cardiovascular disease (CVD) [3,4]. "
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