Virulence Factors That Modulate the Cell Biology of Listeria Infection and the Host Response

Institut Pasteur, Unité des Interactions Bactéries-Cellules, Paris, France.
Advances in Immunology (Impact Factor: 5.96). 12/2012; 113:19-32. DOI: 10.1016/B978-0-12-394590-7.00007-5
Source: PubMed


The Gram-positive bacterial pathogen Listeria monocytogenes has become one of the best studied models in infection biology. This review will update our knowledge of Listeria virulence factors and highlight their role during the Listeria infection process.

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    • "L. monocytogenes is considered an environmental pathogen as it is capable of life as a saprophyte in the outside environment while also maintaining the ability to invade and replicate within mammalian cells (Xayarath and Freitag, 2012). As part of the transition between life in the outside environment to life within the cytosol, L. monocytogenes increases the expression of secreted virulence factors that facilitate intracellular survival by promoting cell entry, bacterial escape from host vacuoles, replication within the cytosol, and spread to adjacent cells (Shetron-Rama et al., 2003; Mueller and Freitag, 2005; Port and Freitag, 2007; Alonzo and Freitag, 2010; de Las Heras et al., 2011; Mostowy and Cossart, 2012). The expression of many of the secreted virulence "
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