A retrospective analysis of glycol and toxic alcohol ingestion: Utility of anion and osmolal gaps

Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA, 52242, USA. .
BMC Clinical Pathology 01/2012; 12(1):1. DOI: 10.1186/1472-6890-12-1
Source: PubMed


Patients ingesting ethylene glycol, isopropanol, methanol, and propylene glycol ('toxic alcohols') often present with non-specific signs and symptoms. Definitive diagnosis of toxic alcohols has traditionally been by gas chromatography (GC), a technique not commonly performed on-site in hospital clinical laboratories. The objectives of this retrospective study were: 1) to assess the diagnostic accuracy of the osmolal gap in screening for toxic alcohol ingestion and 2) to determine the common reasons other than toxic alcohol ingestion for elevated osmolal gaps.
Electronic medical records from an academic tertiary care medical center were searched to identify all patients in the time period from January 1, 1996 to September 1, 2010 who had serum/plasma ethanol, glucose, sodium, blood urea nitrogen, and osmolality measured simultaneously, and also all patients who had GC analysis for toxic alcohols. Detailed chart review was performed on all patients with osmolal gap of 9 or greater.
In the study period, 20,669 patients had determination of serum/plasma ethanol and osmolal gap upon presentation to the hospitals. There were 341 patients with an osmolal gap greater than 14 (including correction for estimated contribution of ethanol) on initial presentation to the medical center. Seventy-seven patients tested positive by GC for one or more toxic alcohols; all had elevated anion gap or osmolal gap or both. Other than toxic alcohols, the most common causes for an elevated osmolal gap were recent heavy ethanol consumption with suspected alcoholic ketoacidosis, renal failure, shock, and recent administration of mannitol. Only 9 patients with osmolal gap greater than 50 and no patients with osmolal gap greater than 100 were found to be negative for toxic alcohols.
Our study concurs with other investigations that show that osmolal gap can be a useful diagnostic test in conjunction with clinical history and physical examination.

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    • "Dilution protocols were modified following identification of this problem.[17] A protocol for evaluation of possible toxic alcohol or glycol exposure was developed based on osmolal gap.[1819] "
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    03/2014; 5(1):13. DOI:10.4103/2153-3539.129450
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    • "). However, even if not directly toxic, propylene glycol increases plasma osmolality and complicates the use of osmolal gap in clinical diagnosis and management, especially for patients receiving multiple doses of propylene glycolcontaining medication, as may be done in intubated patients requiring extended sedation (Krasowski et al. 2012 "
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    SpringerPlus 12/2013; 2(1):203. DOI:10.1186/2193-1801-2-203
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