Article

Hypohomocysteinemia: a potentially treatable cause of peripheral neuropathology?

Sunstone Medical Research, LLC, Medford, OR 97504, USA.
Physical Medicine and Rehabilitation Clinics of North America (impact factor: 1.4). 02/2012; 23(1):59-65, x. DOI:10.1016/j.pmr.2011.11.001 pp.59-65, x
Source: PubMed

ABSTRACT Perturbations of homocysteine metabolism are associated with increased risk for cardiovascular disease, stroke, dementia, and depression, among other major diseases. To assess the relationship between hypohomocysteinemia (HH) and idiopathic peripheral neuropathy (IPN), a retrospective review of 37,442 patients from a tertiary medical clinic was performed. Of patients with HH, 5.9% had IPN versus 0.6% of patients without IPN. Overall, 41% of patients with HH had IPN. These observations indicate that although HH is uncommon in the general population, there is a striking relationship between HH and the incidence of IPN. This article discusses the clinical ramifications of these findings.

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Keywords

article discusses
 
cardiovascular disease
 
clinical ramifications
 
HH
 
homocysteine metabolism
 
hypohomocysteinemia
 
idiopathic peripheral neuropathy
 
major diseases
 
retrospective review
 
striking relationship
 
tertiary medical clinic