Article

Role of the promyelocytic leukaemia protein in cell death regulation.

Samantha Dickson Brain Cancer Unit, UCL Cancer Institute, 72 Huntley Street, London WC1E 6BT, UK.
Cell Death & Disease (Impact Factor: 5.18). 01/2012; 3:e247. DOI: 10.1038/cddis.2011.122
Source: PubMed

ABSTRACT The promyelocytic leukaemia gene PML was originally identified at the t(15;17) translocation of acute promyelocytic leukaemia, which generates the oncogene PML-retinoic acid receptor α. PML epitomises a subnuclear structure called PML nuclear body. Current models propose that PML through its scaffold properties is able to control cell growth and survival at many different levels. Here we discuss the current literature and propose new avenues for investigation.

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