Pneumococcal Bacteremia in a Vaccinated Pediatric Sickle Cell Disease Population

Division of Emergency Medicine, The Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
The Pediatric Infectious Disease Journal (Impact Factor: 2.72). 01/2012; 31(5):534-6. DOI: 10.1097/INF.0b013e3182480fed
Source: PubMed


The incidence of pneumococcal disease in sickle cell disease declined significantly with penicillin prophylaxis as well as with the pneumococcal polysaccharide and heptavalent conjugate vaccines. In this report, we describe our experience with pneumococcal bacteremia in pediatric patients with sickle cell disease in the post-heptavalent pneumococcal conjugate vaccine era. Despite established prophylactic strategies, pneumococcal bacteremia continues to occur in patients with sickle cell disease.

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