Magnetic resonance imaging appearance of scurvy with gelatinous bone marrow transformation

Department of Radiology and Medical Imaging, University of Virginia Health System, Charlottesville, VA 22908, USA.
Skeletal Radiology (Impact Factor: 1.51). 03/2012; 41(3):357-60. DOI: 10.1007/s00256-011-1350-9
Source: PubMed


Scurvy is a lethal but treatable disease that is rare in industrialized countries. Caused by vitamin C deficiency, it is most prevalent in persons of low socioeconomic status and smokers. Low levels of circulating vitamin C result in poor collagen fiber formation that, in turn, leads to demineralized bones, microfractures, and poor healing. Here we report a case of scurvy in a 5-year-old boy with normal radiographs in whom initial concern for leukemia based upon magnetic resonance imaging and clinical presentation led to a bone marrow biopsy revealing gelatinous transformation.

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