Magnetic resonance imaging appearance of scurvy with gelatinous bone marrow transformation
ABSTRACT Scurvy is a lethal but treatable disease that is rare in industrialized countries. Caused by vitamin C deficiency, it is most prevalent in persons of low socioeconomic status and smokers. Low levels of circulating vitamin C result in poor collagen fiber formation that, in turn, leads to demineralized bones, microfractures, and poor healing. Here we report a case of scurvy in a 5-year-old boy with normal radiographs in whom initial concern for leukemia based upon magnetic resonance imaging and clinical presentation led to a bone marrow biopsy revealing gelatinous transformation.
- SourceAvailable from: Michael J CallahanPediatric Radiology 03/2013; 43(1). DOI:10.1007/s00247-012-2583-z · 1.65 Impact Factor
Article: Marrow: red, yellow and bad[Show abstract] [Hide abstract]
ABSTRACT: Bone marrow is one of the largest and most dynamic tissues in the body, and it is well-depicted on conventional MRI sequences. However, often only perfunctory attention is paid to the bone marrow on musculoskeletal imaging studies, raising the risk of delayed or missed diagnoses. To guide appropriate recognition of normal variants and pathological processes involving the marrow compartment, this article describes and depicts the physiological spatiotemporal pattern of conversion of hematopoietic red marrow to fatty yellow marrow during childhood and adolescence, and the characteristic imaging findings of disorders involving marrow hyperplasia/reconversion, marrow infiltration/deposition and marrow depletion/failure.Pediatric Radiology 03/2013; 43(1). DOI:10.1007/s00247-012-2582-0 · 1.65 Impact Factor
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ABSTRACT: Scurvy results from a deficiency of vitamin C and is rarely seen in the United States. We describe the MRI findings of a case of scurvy in an autistic child with food-avoidant behavior. Advanced imaging is rarely performed in clinically well-understood disease entities such as scurvy. Typical radiographic findings are well described leading to definitive diagnosis, although the findings can be missed or misinterpreted given the rarity of scurvy in daily practice. To our knowledge, MRI features of scurvy in children in the US have been described in only one case report. This case of scurvy in an autistic child with food-avoidant behavior emphasizes that classic nutritional deficiencies, despite their rarity, must be included in the differential diagnosis of at-risk populations.Pediatric Radiology 04/2013; 43(10). DOI:10.1007/s00247-013-2688-z · 1.65 Impact Factor