Magnetic resonance imaging appearance of scurvy with gelatinous bone marrow transformation.
ABSTRACT Scurvy is a lethal but treatable disease that is rare in industrialized countries. Caused by vitamin C deficiency, it is most prevalent in persons of low socioeconomic status and smokers. Low levels of circulating vitamin C result in poor collagen fiber formation that, in turn, leads to demineralized bones, microfractures, and poor healing. Here we report a case of scurvy in a 5-year-old boy with normal radiographs in whom initial concern for leukemia based upon magnetic resonance imaging and clinical presentation led to a bone marrow biopsy revealing gelatinous transformation.
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ABSTRACT: In modern times scurvy is a rarely encountered disease caused by ascorbic acid (vitamin C) deficiency. However, sporadic cases of scurvy persist, particularly within the pediatric population. Recent individual case reports highlight an increased incidence of scurvy among patients with autism or developmental delay, with isolated case reports detailing the magnetic resonance imaging (MRI) findings of scurvy in these pediatric populations. We present the MRI findings of scurvy in four patients with autism or developmental delay, and review the literature on MRI findings in pediatric patients with scurvy. Despite its rarity, the radiologist must consider scurvy in a pediatric patient with a restricted diet presenting with arthralgia or myalgia.Skeletal Radiology 08/2014; 44(2). DOI:10.1007/s00256-014-1962-y · 1.74 Impact Factor
Pediatric Radiology 03/2013; 43(1). DOI:10.1007/s00247-012-2583-z · 1.65 Impact Factor
Article: Marrow: red, yellow and bad[Show abstract] [Hide abstract]
ABSTRACT: Bone marrow is one of the largest and most dynamic tissues in the body, and it is well-depicted on conventional MRI sequences. However, often only perfunctory attention is paid to the bone marrow on musculoskeletal imaging studies, raising the risk of delayed or missed diagnoses. To guide appropriate recognition of normal variants and pathological processes involving the marrow compartment, this article describes and depicts the physiological spatiotemporal pattern of conversion of hematopoietic red marrow to fatty yellow marrow during childhood and adolescence, and the characteristic imaging findings of disorders involving marrow hyperplasia/reconversion, marrow infiltration/deposition and marrow depletion/failure.Pediatric Radiology 03/2013; 43(1). DOI:10.1007/s00247-012-2582-0 · 1.65 Impact Factor