Article

Muscarinic receptor agonists and antagonists: effects on inflammation and immunity.

School of Public Health, Harvard University, 665 Huntington Avenue, Boston, MA 02115, USA.
Handbook of experimental pharmacology 01/2012; DOI: 10.1007/978-3-642-23274-9_17
Source: PubMed

ABSTRACT In this chapter, we will review what is known about muscarinic regulation of immune cells and the contribution of immune cell muscarinic receptors to inflammatory disease and immunity. In particular, immune cell expression of cholinergic machinery, muscarinic receptor subtypes and functional consequences of agonist stimulation will be reviewed. Lastly, this chapter will discuss the potential therapeutic effects of selective antagonists on immune cell function and inflammatory disease in recent animal studies and human clinical trials.

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