An AD-Related Neuroprotector Rescues Transformed Rat Retinal Ganglion Cells from CoCl2-Induced Apoptosis

Department of Ophthalmology, Shengjing Hospital, China Medical University, Sanhao street 36, Heping district, Shenyang 110004, Liaoning Province, China.
Journal of Molecular Neuroscience (Impact Factor: 2.76). 01/2012; 47(1):144-9. DOI: 10.1007/s12031-011-9701-5
Source: PubMed

ABSTRACT Some ocular diseases characterized by apoptotic death of retinal ganglion cells (RGCs) and Alzheimer's disease (AD) are chronic neurodegenerative disorders and have similarities in neuropathology. Humanin (HN) is known for its ability to suppress neuronal death induced by AD-related insults. In present study, we investigated the neuroprotective effects of HN on hypoxia-induced toxicity in RGC-5 cells. Hypoxia mimetic compound cobalt chloride (CoCl₂) could increase the cell viability loss and apoptosis, whereas HN can significantly attenuate these effects. This finding may provide new therapeutics for the retinal neurodegenerative diseases targeting neuroprotection.

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