How the DNA damage response determines the fate of HTLV-1 Tax-expressing cells.

National Fund for Scientific Research, Gembloux Agro-Bio Tech and Interdisciplinary Cluster for Applied Genoproteomics (GIGA), University of Liège, Belgium.
Retrovirology (Impact Factor: 5.66). 01/2012; 9:2. DOI: 10.1186/1742-4690-9-2
Source: PubMed

ABSTRACT How the Human T lymphotropic virus type 1 (HTLV-1) Tax protein stimulates proliferation while triggering cell cycle arrest and senescence remains puzzling. There is also a debate about the ability of Tax to activate or inhibit the DNA damage response. Here, we comment on these different activities and propose a conceptual rationale for the apparently conflicting observations.

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