Silver-Mediated Oxidative C-H/C-H Functionalization: A Strategy To Construct Polysubstituted Furans

College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, P. R. China.
Journal of the American Chemical Society (Impact Factor: 12.11). 03/2012; 134(13):5766-9. DOI: 10.1021/ja301153k
Source: PubMed


A novel silver-mediated highly selective oxidative C-H/C-H functionalization of 1,3-dicarbonyl compounds with terminal alkynes for the creation of polysubstituted furans and pyrroles in one step has been demonstrated. Promoted by the crucial silver species, perfect selectivity and good to excellent yields could be achieved. This protocol represents an extremely simple and atom-economic way to construct polysubstituted furans and pyrroles from basic starting materials under mild conditions.

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