Updates on Human Papillomavirus and Genital Warts and Counseling Messages From the 2010 Sexually Transmitted Diseases Treatment Guidelines

Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
Clinical Infectious Diseases (Impact Factor: 8.89). 12/2011; 53 Suppl 3(suppl 3):S143-52. DOI: 10.1093/cid/cir703
Source: PubMed


In April 2009, experts on sexually transmitted diseases (STDs) were convened to review updates on STD prevention and treatment in preparation for the revision of the Centers for Disease Control and Prevention (CDC) STD Treatment Guidelines. At this meeting, there was a discussion of important updates on human papillomavirus (HPV), genital warts, and cervical cancer screening.
Key questions were identified with assistance from an expert panel, and systematic reviews of the literature were conducted searching the English-language literature of the PubMed computerized database (US National Library of Medicine). The available evidence was reviewed, and new information was incorporated in the 2010 CDC STD Treatment Guidelines.
Two HPV vaccines are now available, the quadrivalent HPV vaccine and the bivalent HPV vaccine; either vaccine is recommended routinely for girls aged 11 or 12 years. The quadrivalent HPV vaccine may be given to boys and men aged 9-26 years. A new patient-applied treatment option for genital warts, sinecatechins 15% ointment, is available and recommended for treatment of external genital warts. This product is a mixture of active ingredients (catechins) from green tea. Finally, updated counseling guidelines and messages about HPV, genital warts, and cervical cancer are included.
This manuscript highlights updates to the 2010 CDC STD Treatment Guidelines for HPV and genital warts. Important additions to the 2010 STD Treatment Guidelines include information on prophylactic HPV vaccine recommendations, new patient-applied treatment options for genital warts, and counseling messages for patients on HPV, genital warts, cervical cancer screening, and HPV tests.

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    • "Human Papilloma Viruses (HPVs) comprise a large group of approximately 120 genotypes that infect the epithelia of the skin or mucosa and most commonly cause benign Papillomas. Anogenital HPV is a highly prevalent sexually transmitted infection by more than 40 types of HPV, seen predominantly in young adults (1–4). "
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    ABSTRACT: Genital warts, due to specific types of the human papillomavirus, have long been regarded as one of the most important causes of cervical cancer and one of the most common cause of Sexually Transmited Diseases (STDs). Over the years, it has been the focus of several studies in order to find the best effective approach to eradicate the virus, however there are still controversies regarding this matter. We compared efficacy of the two physical ablative therapies; Liquid Nitrogen and CO(2) laser. One hundred and sixty patients, with external genital warts, were divided into two groups. Each group consisted of 80 patients treated with CO(2)-laser or cryotherapy. Clearance and recurrence rates were evaluated for 3 months. Complete clearance was achieved in 76 lesions (95%) treated by CO(2)-laser and 37 lesions (46.2%) treated by cryotherapy which was significantly different (p < 0.001). In the CO(2)-laser group, lesions required only one treatment to clear while in the cryotherapy group, lesions required two (12%) even up to three (12.2%) treatments for some patients to clear completely. Laser therapy was associated with less recurrence rate compared to cryotherapy (0.05% Vs 0.18%). Generally, the efficacy of CO(2) laser treatment of external genital warts was approximately two fold greater than cryotherapy and it was associated with lower recurrence rate.
    Iranian Journal of Microbiology 12/2012; 4(4):187-90.
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    ABSTRACT: Common warts (verruca vulgaris) are benign epithelial proliferations associated with human papillomavirus (HPV) infection. Salicylic acid and cryotherapy are the most frequent treatments for common warts, but can be painful and cause scarring, and have high failure and recrudescence rates. Topical vitamin A has been shown to be a successful treatment of common warts in prior informal studies. The subject is a healthy, physically-active 30 old female with a 9 year history of common warts on the back of the right hand. The warts resisted treatment with salicylic acid, apple cider vinegar and an over-the-counter blend of essential oils marketed for the treatment of warts. Daily topical application of natural vitamin A derived from fish liver oil (25,000 IU) led to replacement of all the warts with normal skin. Most of the smaller warts had been replaced by 70 days. A large wart on the middle knuckle required 6 months of vitamin A treatment to resolve completely. Retinoids should be further investigated in controlled studies to determine their effectiveness in treating common warts and the broad range of other benign and cancerous lesions induced by HPVs.
    Virology Journal 01/2012; 9(1):21. DOI:10.1186/1743-422X-9-21 · 2.18 Impact Factor
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    EMBO Reports 11/2012; 13(12). DOI:10.1038/embor.2012.180 · 9.06 Impact Factor
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