Pinguecula and Diabetes Mellitus

Department of Ophthalmology, Toranomon Hospital, Minato-ku, Tokyo, Japan.
Cornea (Impact Factor: 2.04). 03/2012; 31(3):264-8. DOI: 10.1097/ICO.0b013e3182254170
Source: PubMed


To assess the relationship between age and the incidence and severity of pinguecula in patients with diabetes mellitus, and to compare the grade of pinguecula between control subjects and patients with diabetes.
A total of 160 patients with type 2 diabetes aged 31 to 70 years (DM group) and 160 control subjects aged 31 to 70 years (control group) were enrolled. The grade of pinguecula at 2 locations (nasal and temporal) was assessed in all subjects by a grading system.
There was an age-related increase in the grade of pinguecula in both the DMgroup (r = 0.52; P < 0.0001) and the control group (r = 0.51; P < 0.0001). The grade and prevalence of pinguecula were higher in the DM group than in the control group for pinguecula of the nasal conjunctiva (grade: P < 0.0001; and prevalence: 55.0% vs. 40.0%, P = 0.0072) and the temporal conjunctiva (grade: P < 0.0001; and prevalence: 54.4% vs. 40.0%, P = 0.0100). Multivariate logistic regression analysis revealed that age and diabetes were associated with an increased prevalence of nasal or temporal pinguecula (all P < 0.05). Diabetes mellitus was independently associated with the severity of pinguecula (nasal: odds ratio = 1.19; temporal: odds ratio = 1.22) after adjustment for age.
This is the first assessment of the relationship between pinguecula and diabetes mellitus. Our results suggest that diabetes mellitus may be a factor associated with the development of pinguecula.

20 Reads
  • [Show abstract] [Hide abstract]
    ABSTRACT: The sirtuins are a highly conserved family of nicotinamide adenine dinucleotide (NAD+)-dependent histone deacetylases that helps regulate the lifespan of diverse organisms. The human genome encodes seven different sirtuins (SIRT1-7), which share a common catalytic core domain but possess distinct N- and C-terminal extensions. Dysfunction of some sirtuins have been associated with age-related diseases, such as cancer, type II diabetes, obesity-associated metabolic diseases, neurodegeneration, and cardiac aging, as well as the response to environmental stress. SIRT1 is one of the targets of resveratrol, a polyphenolic SIRT1 activator that has been shown to increase the lifespan and to protect various organs against aging. A number of animal studies have been conducted to examine the role of sirtuins in ocular aging. Here we review current knowledge about SIRT1 and ocular aging. The available data indicate that SIRT1 is localized in the nucleus and cytoplasm of cells forming all normal ocular structures, including the cornea, lens, iris, ciliary body, and retina. Upregulation of SIRT1 has been shown to have an important protective effect against various ocular diseases, such as cataract, retinal degeneration, optic neuritis, and uveitis, in animal models. These results suggest that SIRT1 may provide protection against diseases related to oxidative stress-induced ocular damage, including cataract, age-related macular degeneration, and optic nerve degeneration in glaucoma patients.
    Experimental Eye Research 07/2013; 116. DOI:10.1016/j.exer.2013.07.017 · 2.71 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: To investigate the relationship between pinguecula and the use of tandoor ovens. A total of 539 women, ranging in age from 20 to 86y who attended an outpatient clinic were enrolled. All the patients were asked whether they used tandoor ovens. Women exposed to tandoor ovens (n=286) were accepted as participants in the study group and they were compared with participants in the control group (n=253). The age, presence of pinguecula, duration of exposure to tandoor ovens as years and occupations were recorded for all the subjects. Mean duration for exposure to tandoor was 20.26y (range 1-62y) in the study group. The rate of pinguecula in the study group was 82.2% (235/286), and the rate in the control group was 37.5% (95/253); this difference was statistically significant (P<0.05). Pinguecula was seen in 61.2% (330/539) of all the participants. Pinguecula is strongly associated with exposure to tandoor ovens.
    International Journal of Ophthalmology 12/2014; 7(6):1014-6. DOI:10.3980/j.issn.2222-3959.2014.06.19 · 0.12 Impact Factor