Article

Basic Clinical and Laboratory Features of Filoviral Hemorrhagic Fever

Department of Preventive Medicine, Infectious Disease Clinical Research Program, Uniformed Services University of Health Sciences, Bethesda, Maryland 20814-5119, USA.
The Journal of Infectious Diseases (Impact Factor: 5.85). 11/2011; 204 Suppl 3:S810-6. DOI: 10.1093/infdis/jir299
Source: PubMed

ABSTRACT The filoviruses Marburg and Ebola cause severe hemorrhagic fever (HF) in humans. Beginning with the 1967 Marburg outbreak, 30 epidemics, isolated cases, and accidental laboratory infections have been described in the medical literature. We reviewed those reports to determine the basic clinical and laboratory features of filoviral HF. The most detailed information was found in descriptions of patients treated in industrialized countries; except for the 2000 outbreak of Ebola Sudan HF in Uganda, reports of epidemics in central Africa provided little controlled or objective clinical data. Other than the case fatality rate, there were no clear differences in the features of the various filovirus infections. This compilation will be of value to medical workers responding to epidemics and to investigators attempting to develop animal models of filoviral HF. By identifying key unanswered questions and gaps in clinical data, it will help guide clinical research in future outbreaks.

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    [Show abstract] [Hide abstract]
    ABSTRACT: Abstract Ebola Hemorrhagic Fever (EHF) is a rare viral disease, caused by infection with Ebola virus. It is characterized by abrupt onset of fever, chills, malaise, gastrointestinal, respiratory, cutaneous, and central nervous system manifestations. In 2014, the World Health Organization (WHO) declared the outbreak of EHF to be a Public Health Emergency of International Concern. Up to now, no specific therapeutics or vaccines have been approved for this lethal disease. Herein, we have reviewed EHF in terms of virology, immunology, epidemiological profile, transmission, clinical and para-clinical manifestations, prevention and, treatment with focus on dermatological points.