Open-label trial of a multi-strain synbiotic in cats with chronic diarrhea

Colorado State University, Veterinary Teaching Hospital, 300 West Drake Road, Fort Collins, CO 80523, USA.
Journal of feline medicine and surgery 04/2012; 14(4):240-5. DOI: 10.1177/1098612X11434386
Source: PubMed


This study was designed to test the hypothesis that in cats with chronic diarrhea the daily administration of a proprietary synbiotic (Proviable-DC) would result in an improvement in stool character, as assessed by the owner. Adult cats with chronic diarrhea were recruited for the study and screened for systemic diseases. Fecal flotation, wet mount, immunofluorescence assay (IFA) for Giardia and Cryptosporidium species, and Tritrichomonas species polymerase chain reactions (PCRs) were used to screen for intestinal parasitism. The synbiotic was administered for 21 days; otherwise, no changes were made to ongoing treatment(s) or diet. The severity of the diarrhea was assessed using a standardized fecal scoring system and the owner's subjective perception before, and after, supplementation. The mean fecal score for the 53 cats completing the study decreased from 6.0 to 4.4, representing a significantly (P <0.001) firmer stool character. Seventy-two percent of owners perceived an improvement in their cat's diarrhea following a 21-day course of synbiotic supplementation.

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    • "Probiotics use in cats with diarrhoea has shown an improvement in faecal quality (Hart et al. 2012). Studies of Lactobacillus acidophilus in dogs and cats have shown a decrease in clostridial species. "
    Journal of Small Animal Practice 09/2014; 55(9). DOI:10.1111/jsap.12263 · 1.09 Impact Factor
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    • "Chronic enteropathies, such as inflammatory bowel disease (IBD) have been associated with changes in the proportions of specific bacterial groups, especially Enterobacteriaceae and Desulfovibrio spp. in some studies (Inness et al., 2007; Janeczko et al., 2008). Conversely, some recent clinical studies suggest that the administration of specific bacterial strains or products intended to alter the intestinal microbiota (i.e., probiotics, prebiotics, or synbiotics) have the potential to improve the frequency and/or duration of diarrhea in a subset of cats with specific acute or chronic GI diseases (Bybee et al., 2011; Hart et al., 2012). While the cat is an obligate carnivore, most commercial feline diets contain moderate quantities of carbohydrates. "
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