Association of PPAR-γ gene polymorphisms with obesity and obesity-associated phenotypes in North Indian population.

Chatrapati Shahuji Maharaj Medical University, Lucknow, U.P., India.
American Journal of Human Biology (Impact Factor: 1.7). 07/2012; 24(4):454-9. DOI: 10.1002/ajhb.22245
Source: PubMed


The worldwide increasing prevalence of obesity is considered as a major health problem. Peroxisome proliferator-activated receptor gamma (PPAR-γ) controls adipocyte differentiation and regulates a number of genes associated with energy homeostasis. In this study, we investigated the association of PPAR-γ gene Pro12Ala (rs1801282) and C1431T (rs3856806) polymorphisms with morbid obesity and related phenotypes, in north Indian population.
A total of 6,42 subjects, 309, obese and 333 nonobese individuals were included in this case-control study. Insulin, adiponectin, glucose, and lipid levels were estimated using standard protocols. All subjects were genotyped by PCR restriction fragment length polymorphism (PCR-RFLP) method.
The ProAla+AlaAla genotypes of PPAR-γ Pro12Ala were significantly associated with higher risk of obesity while C1431T polymorphism did not show any significant association. None of the haplotypes showed association with morbid obesity. However, a strong association of variant genotypes was observed with higher levels of insulin, HOMA-IR, and lower serum adiponectin concentrations.
PPAR-γ gene polymorphisms influence obesity and obesity phenotype in a complex manner, probably involving insulin resistance in north Indian population.

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Available from: Jai Prakash, May 31, 2015
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    • "In a previous study[12], we also found that those carrying rs2920502CG and CG/GG genotype had a significantly increased risk of metabolic syndrome and rs4240711GG and AG/GG, rs4842194 CC and CT/CC genotypes were all associated with prominent protective effects for metabolic syndrome. Up to now, numerous studies have focused on the association between C1431T variant (rs3856806) of PPAR-γ and the risk of metabolic syndrome, type 2 diabetes and obesity in several populations[24]–[26], but the conclusions are conflicting. Li et al.[24] reported that polymorphism C1431T of exon 6 of PPAR-γ was associated with metabolic syndrome risks in a Chinese population study of 423 cases with metabolic syndrome and families without metabolic syndrome. "
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    • "Until now there were no reports on polymorphism of dog adipokines, except one that concerned the PPARG gene. It was suggested by Prakash et al. (2012) that polymorphism of human PPARG, which plays a crucial role in adipogenesis, is associated with obesity. In the canine PPARG gene a silent SNP (1362C>T) in exon 7 was described by Nishii et al. (2007). "
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