Microfluidic diagnostics for the developing world

Department of Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA 16802, USA.
Lab on a Chip (Impact Factor: 6.12). 03/2012; 12(8):1412-6. DOI: 10.1039/c2lc90022j
Source: PubMed


For more than a decade, it has been expected that microfluidic technology would revolutionize the healthcare industry with simple, inexpensive, effective, and ubiquitous miniature diagnostic devices. To date, however, microfluidics has not yet been able to live up to these expectations. This fact has led to the recent development of new philosophies and methodologies for microfluidic diagnostics. In this Focus article, we will discuss some of the latest breakthroughs that could significantly impact medical diagnostics in the developing world.

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    • "They possess advantages of being inexpensive, easy to use, lightweight and low cost [1] [2]. These devices are capable of detecting very small molecules such as glucose, lactose, alcohol, cholesterol, uric acid, antibody and antigen [3] [4]. For their production , different fabrication techniques such as photolithography, inkjet printing, wax patterning and plasma treatment of hydrophobic paper have been used [5]. "
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    ABSTRACT: This study focuses on the fabrication of a novel, flexible and disposable textile based biosensing platform by the use of an absorbent microfibrous nonwoven substrate as the base material. This platform was fabricated via photolithography technique. Physical barriers were designed using a hydrophobic photo-resist polymer which defined the liquid penetration pathways on the fabric surface. A good hydrophilic/hydrophobic contrast of the fabricated patterns on the fabric and a well-controlled liquid capillary penetration was achieved in the patterns. The potential of the system was tested by constructing an enzyme biosensor based on colorimetric detection of hydrogen peroxide. To obtain a more enhanced and reproducible signal, the reservoirs were modified with gelatin and a linear working range of 0.1–0.6 μM H2O2 was obtained. The system could work on temperatures as high as 50 °C without any loss in the signal and in a pH range of 3.0–7.0. This bio-sensing platform may later be combined by H2O2 producing oxidases such as glucose oxidase, lactate oxidase, etc. and used for the rapid detection of various kinds of important analytes.
    Sensors and Actuators B Chemical 03/2015; 208:475-484. DOI:10.1016/j.snb.2014.11.042 · 4.10 Impact Factor
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    • "Different fabrication methods for analytical devices have been used such as screen (wax) printing, ink-jet printing, plotting, plasma treatment and photolithography. It is difficult to form hydrophobic barriers through the entire thickness of substrate with uniform width, using simple printing technologies [3] [4]. "
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    ABSTRACT: A novel textile-based analytical device with a simultaneous, rapid, sensitive and qualitative response for analyte detection that may have a potential use in different body fluids such as sweat, blood, saliva and urine is proposed in this study as an alternative to its paper-based counterparts. A porous polypropylene spunbond nonwoven was used as base fabric which is superior to paper with higher tear and crinkle resistance, flexibility and wearability.
    01/2014; 490-491:274-279. DOI:10.4028/
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    ABSTRACT: This paper describes an efficient and high throughput method for fabricating three-dimensional (3D) paper-based microfluidic devices. The method avoids tedious alignment and assembly steps and eliminates a major bottleneck that has hindered the development of these types of devices. A single researcher now can prepare hundreds of devices within 1 h.
    Lab on a Chip 06/2012; 12(15):2630-3. DOI:10.1039/c2lc40331e · 6.12 Impact Factor
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