Article

Parent psychopathology and offspring mental disorders: Results from the WHO World Mental Health Surveys

Division of General Pediatrics, Children's Hospital Boston, Harvard Medical School, 300 Longwood Ave, Boston, MA 02115, USA.
The British journal of psychiatry: the journal of mental science (Impact Factor: 7.34). 03/2012; 200(4):290-9. DOI: 10.1192/bjp.bp.111.101253
Source: PubMed

ABSTRACT Associations between specific parent and offspring mental disorders are likely to have been overestimated in studies that have failed to control for parent comorbidity.
To examine the associations of parent with respondent disorders.
Data come from the World Health Organization (WHO) World Mental Health Surveys (n = 51 507). Respondent disorders were assessed with the Composite International Diagnostic Interview and parent disorders with informant-based Family History Research Diagnostic Criteria interviews.
Although virtually all parent disorders examined (major depressive, generalised anxiety, panic, substance and antisocial behaviour disorders and suicidality) were significantly associated with offspring disorders in multivariate analyses, little specificity was found. Comorbid parent disorders had significant sub-additive associations with offspring disorders. Population-attributable risk proportions for parent disorders were 12.4% across all offspring disorders, generally higher in high- and upper-middle- than low-/lower-middle-income countries, and consistently higher for behaviour (11.0-19.9%) than other (7.1-14.0%) disorders.
Parent psychopathology is a robust non-specific predictor associated with a substantial proportion of offspring disorders.

2 Followers
 · 
214 Views
 · 
115 Downloads
  • Source
    • "Although there is empirical support for the relationship between childhood exposure to parental suicidal behavior and the development of suicidal behavior (Brent & Melhem, 2008; Bronisch & Lieb, 2008; Kuramoto et al., 2009; Wilcox et al., 2010), studies on the relationship between parental suicidal behavior and the development of SUDs are limited. The most recent WHO World Mental Health Survey study found that parental suicide attempt and/or death only significantly predicted substance abuse in offspring when both parents died of suicide (McLaughlin et al., 2012). Another study of young adults in Sweden found that those who had lost a parent to suicide during childhood were at higher risk for later hospitalization for drug use than those who had not (Wilcox et al, 2010). "
    [Show abstract] [Hide abstract]
    ABSTRACT: Childhood exposure to parental suicidal behavior has been linked to a variety of adverse behavioral and health outcomes. However, relatively little is known about the degree to which such exposure may place individuals at risk for a substance use disorder (SUD). Employing data from the National Epidemiologic Survey on Alcohol and Related Conditions, we compared the prevalence of SUDs among those who experienced childhood exposure to parental suicide attempts. Childhood exposure to parental suicide attempts was not associated with increased risk for the development of alcohol, cannabis, or cocaine use disorders. However, individuals who were exposed to aparental suicide attempt as children were significantly more likely to have met criteria for stimulant (AOR=1.40, 95% CI=1.18-1.67), sedative (AOR=1.24, 95% CI=1.04-1.47), tranquilizer (AOR=1.78, 95% CI=1.45-2.20), and opioid (AOR=1.41, 95% CI=1.19-1.67) use disorders in their lifetime. No significant gender differences were identified with respect to the magnitude of the relationship between exposure to parental suicide attempts and SUD risk among men and women. Findings suggest that, controlling for an array of sociodemographic, parental, mental health, and childhood adversity confounds, childhood exposure to parental suicide attempts is a vulnerability factor for low prevalence illicit drugs (i.e. stimulants, sedatives, tranquilizers, opioids), but not for more commonly used substances. Copyright © 2015 Elsevier Ltd. All rights reserved.
    Addictive Behaviors 03/2015; 46. DOI:10.1016/j.addbeh.2015.03.008 · 2.44 Impact Factor
  • Source
    • "The CIDI-Auto is a structured diagnostic interview that can produce DSM-IV and ICD-10 diagnosis for mental health problems and substance abuse and dependence. The CIDI has high concurrent validity (McLaughlin et al., 2012). "
    [Show abstract] [Hide abstract]
    ABSTRACT: Little is known about the extent to which parental conflict and violence differentially impact on offspring mental health and substance use. Using data from a longitudinal birth cohort study this paper examines: whether offspring exposure to parental intimate partner violence (involving physical violence which may include conflicts and/or disagreements) or parental intimate partner conflict (conflicting interactions and disagreements only) are associated with offspring depression, anxiety and substance use in early adulthood (at age 21); and whether these associations are independent of maternal background, depression and anxiety and substance use. Data (n = 2,126 women and children) were taken from a large-scale Australian birth-cohort study, the Mater University of Queensland Study of Pregnancy (MUSP). IPC and IPV were measured at the 14-year follow-up. Offspring mental health outcomes – depression, anxiety and substance use were assessed at the 21-year follow-up using the Composite International Diagnostic Interview (CIDI). Offspring of women experiencing IPV at the 14-year follow-up were more likely to manifest anxiety, nicotine, alcohol and cannabis disorders by the 21-year follow-up. These associations remained after adjustment for maternal anxiety, depression, and other potential confounders. Unlike males who experience anxiety disorders after exposure to IPV, females experience depressive and alcohol use disorders. IPV predicts offspring increased levels of substance abuse and dependence in young adulthood. Gender differences suggest differential impact.
    Child Abuse & Neglect 07/2014; 38(12). DOI:10.1016/j.chiabu.2014.07.001 · 2.47 Impact Factor
  • Source
    • "Mental disorders in adults contribute to lost work productivity,33 and predict mental disorders in their offspring. 34 "
    [Show abstract] [Hide abstract]
    ABSTRACT: Mental health is essential for individual and public health. To improve mental health, promotion, prevention, and the treatment of disease are required. These three kinds of interventions are interrelated but independent from one another. Although separate efforts for mental health promotion and prevention are needed as well as the public need of mental health promotion and well-being, psychiatrists usually are not accustomed to mental health promotion and prevention. This review introduces an overview of the concept, subjects according to target populations, and various intervention strategies for mental health promotion and prevention of mental illnesses. Based on literatures to date, understanding of developmental psychology, lifestyle medicine, and biopsychosocial contributors of mental health with a macroscopic perspective might help to practice mental health promotion and illness prevention.
    Psychiatry investigation 12/2013; 10(4):307-316. DOI:10.4306/pi.2013.10.4.307 · 1.15 Impact Factor
Show more

Full-text

Download
115 Downloads
Available from
May 28, 2014